A. Qandil, Mohammad A. Hassan, Bilal A. Al-Jeaidi
Aug 8, 2010
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Influential Citations
2
Citations
Quality indicators
Journal
Jordan Journal of Pharmaceutical Sciences
Abstract
A series of 3-aminobenzenesulfonamide derivatives with a 3-N-substituted side chains that contain ureas, thioureas or cyclic amines was designed, synthesized and assayed for antibacterial, anti-candidal and cytotoxic activity. The synthesized compounds exhibited minimal antibacterial activity but showed good anti-candidal activity, especially compounds 2a, 2d, 2e, 3a, 3d, 4b, 4c, 4d, 4j, 4k, 4l and 4m with MIC values ranging from 16-64 µg/mL. The thiourea and urea (compounds 2a-f and 3a-d), but not the cyclic amine derivatives (compounds 4a-m), exhibited significant cytotoxic activity against brine shrimp.