Y. Parthasaradhi, S. Suresh, B. Ranjithkumar
Sep 22, 2015
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0
Influential Citations
3
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Journal
Orbital: The Electronic Journal of Chemistry
Abstract
A series of novel 6-bromo-2-chloro-3-(4-phenyl-[1,2,3]triazol-1-ylmethyl)-quinoline and its derivatives (5a-j) were synthesized in good yields from the intermediates (6-bromo-2-chloro-quinolin-3-yl)-methanol (2) , methanesulfonic acid (6-bromo-2-chloroquinolin-3-yl)methyl methanesulfonate (3) and 3-azidomethyl-6-bromo-2-chloro-quinoline (4) . The synthetic route leading to the title compounds is commenced from commercially available 6-bromo-2-chloro-quinolin-3-carbaldehyde (1) . The chemical structures of the newly synthesized compounds were elucidated by their IR, 1 H and 13 C NMR, mass spectral data and elemental analysis. Further, all the target compounds were screened for their antimicrobial activity against various microorganisms and antimalarial activity towards P. falciparum . DOI: http://dx.doi.org/10.17807/orbital.v7i3.692