R. Pruthi, John Kang, R. Vick
Jul 1, 2002
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Influential Citations
10
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Quality indicators
Journal
The Journal of urology
Abstract
Desmopressin acetate, most commonly used to treat nocturnal enuresis in children, is also used to correct bleeding disorders and as prophylaxis for surgical bleeding in patients with certain bleeding diatheses. However, desmopressin also has a potent antidiuretic effect, impairing free water resorption by the kidney. Consequently, retention of free water and hyponatremia can ensue. We report on a patient who, after treatment with desmopressin as prophylaxis for surgical bleeding secondary to von Willebrand disease, experienced complications of hyponatremia and seizures secondary to water intoxication following laparoscopic radical nephrectomy.