C. M. Legua, P. C. Falcó, A. Cabeza
Nov 15, 1993
Citations
0
Influential Citations
26
Citations
Journal
Analytica Chimica Acta
Abstract
Abstract Sodium 1,2-naphthoquinone 4-sulphonate (NQS) was tested as a reagent for amphetamine in order to develop an extractive-spectrophotometric method for the drug in urine samples. The standard additions method showed the absence of proportional bias error whereas the Youden method and the two standard addition plots method showed the presence of a constant bias error [total Youden blank (TYB)]. Acceptable results were obtained by evaluating the TYB error or by using a placebo (urine sample from a normal subject). The dynamic range of concentrations was 1.4–50 mg 1−1 in urine samples and the detection limit was 0.6 mg 1−1 when 10 ml of urine sample were taken.