K. D. Kumar, R. Letha
Jul 1, 1997
Citations
0
Influential Citations
93
Citations
Quality indicators
Journal
Journal of pharmaceutical and biomedical analysis
Abstract
Paracetamol (Acetaminophen) is one of the most frequently used analgesic drugs. At therapeutic dosage levels the drug is relatively non-toxic. Because of its increasing therapeutic use, its assay and quality control are of vital importance. A number of methods, including instrumental and titrimetric, are available for the quantitative determination of paracetamol in literature. A simple and accurate titrimetric method has been developed for the assay of paracetamol in pure form and in dosage forms, using N,N-dibromo dimethylhydantoin (DBH). Though a number of N-halo compounds are available for the determination of pharmaceuticals, DBH has greater advantages over such reagents.