Determination of dimetridazole in poultry tissues and eggs using liquid chromatography-thermospray mass spectrometry.

doi:10.1039/A703193I

Paper

Determination of dimetridazole in poultry tissues and eggs using liquid chromatography-thermospray mass spectrometry.

Published 1997 · A. Cannavan, D. Kennedy

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Abstract

A method is presented for the determination of the nitroimidazole drug dimetridazole (DMZ) in poultry tissues and eggs by liquid chromatography (LC)-thermospray mass spectrometry (MS). Deuteriated DMZ was employed as an internal standard. Samples were extracted with dichloromethane (muscle) or toluene (liver, egg) and applied to silica gel cartridges. Dimetridazole was eluted with acetone and the eluate evaporated to dryness at 40 degrees C under nitrogen. The residue was redissolved in methanol-water (1 + 1, v/v) and washed with hexane before LC-MS analysis. Quantification was by the ratios of the positive [M + H]+ ions at m/z 142 and 145 for DMZ and the internal standard, respectively. Internal standard corrected recoveries were between 93 and 102% with RSDs between 1.2 and 7.7% for liver spiked at 5, 10 and 20 ng g-1 and muscle and eggs spiked at 5 ng g-1. Absolute recoveries were approximately 80%. The method is suitable for statutory residue testing and was used to measure DMZ residues in eggs from chickens fed a diet containing DMZ at 10 mg kg-1.

Study Snapshot

The method presented for determining dimetridazole in poultry tissues and eggs using liquid chromatography-thermospray mass spectrometry is suitable for statutory residue testing and accurately measures residues in eggs from chickens fed a diet containing 10 mg kg-1 of DMZ.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Determination of dimetridazole in poultry tissues and eggs using liquid chromatography-thermospray mass spectrometry.

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References

The incidence and cause of lasalocid residues in eggs in Northern Ireland.

Lasalocid residues in 66% of Northern Ireland's eggs were found to be due to carry-over from medicated to unmedicated batches of feed during milling processes.

Determination of dimetridazole residues in bovine tissue by liquid chromatography

This study presents a method for detecting and identifying dimetridazole residues in bovine tissue using liquid chromatography, with an average recovery of 84% and a confirmation limit of 5 g kg 1.

The mutagenic action of nitroimidazoles. I. Metronidazole, nimorazole, dimetridazole and ronidazole.

Nitroimidazoles, particularly ronidazole, show high mutagenic activity, potentially impacting their use as human antitrichomonal drugs or poultry preventative measures.

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The method for determining levamisole in animal tissues using liquid chromatography-thermospray mass spectrometry provides accurate and reliable results for statutory testing and measuring concentrations in sheep dosed with a commercial drench containing levamisole.

Determination of fenbendazole and oxfendazole in liver and muscle using liquid chromatography-mass spectrometry.

This method effectively determines fenbendazole and oxfendazole in liver and muscle samples using LC-MS, with high detection limits and recoveries.

Determination of dimetridazole residues in poultry tissues by high-performance liquid chromatography

The developed method effectively determines dimetridazole residues in poultry tissues, with 80% or above recovery rates, making it suitable for use in broiler chickens and turkeys.

Citations

Elimination patterns of dimetridazole in egg of laying hens and tissues of broiler after oral administration

Dimetridazole and its metabolite HMMNI are rapidly eliminated from poultry tissues and eggs, providing a safe and rational use of DMZ in poultry farming.

Efficacy of administration of ampicillin and/or dimetridazole in the management of experimentally induced necrotic enteritis in broiler chickens.

Using ampicillin and dimetridazole together is significantly more effective in controlling necrotic enteritis in broiler chickens than either drug alone.

Confirmatory Analysis of Nitroimidazoles and Hydroxy Metabolites in Honey by Dispersive-Solid Phase Extraction and Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry

The developed UHPLC-MS/MS method effectively confirms the presence of nitroimidazoles and hydroxy metabolites in honey, with recovery ranging from 90.2 to 105.6% and limits of detection and quantification ranging from 0.02 to 0.25 g/kg.

Determination and confirmation of metronidazole, dimetridazole, ronidazole and their metabolites in bovine muscle by LC-MS/MS

The developed LC-MS/MS method effectively detects and confirms the presence of five banned nitroimidazole drugs in bovine muscle, aiding in monitoring illegal use in animal husbandry.

Determination of 5-nitroimidazoles and metabolites in environmental samples by micellar electrokinetic chromatography

This method using micellar electrokinetic chromatography with UV detection effectively determines 5-nitroimidazoles and their metabolites in river water samples, offering an efficient and economical alternative for monitoring these compounds in environmental samples.