Paper
Development of mechanism-based antibacterial synergy between Fmoc-phenylalanine hydrogel and aztreonam.
Published Feb 19, 2020 · A. Gahane, Virender Singh, Ashok Kumar
Biomaterials science
15
Citations
1
Influential Citations
Abstract
Recently, fluorenylmethyloxycarbonyl (Fmoc) conjugated amino acids (Fmoc-AA), especially Fmoc-phenylalanine (Fmoc-F), have been discovered to have antimicrobial properties specific to Gram-positive bacteria including MRSA. Their weak antibacterial activity against Gram-negative bacteria is due to their inability to cross the bacterial membrane. Here in order to increase the antibacterial spectrum of Fmoc-F, we prepared a formulation of Fmoc-F with the Gram-negative specific antibiotic aztreonam (AZT). This formulation displayed antibacterial activity against both Gram-positive and Gram-negative bacteria and significantly reduced the bacterial load in a mouse wound infection model. The combination produced a synergistic effect and higher efficacy against P. aeruginosa due to the increased Fmoc-F permeability by AZT through the bacterial membrane. This combinatorial approach could be an effective strategy for other Fmoc-AA having a Gram-positive specific antibacterial effect for the better management of bacterial wound infections.
Combining Fmoc-phenylalanine hydrogel with aztreonam effectively reduces bacterial load in wound infections, with higher efficacy against P. aeruginosa due to increased Fmoc-F permeability through the bacterial membrane.
Sign up to use Study Snapshot
Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.
Full text analysis coming soon...