V. Swami, B. Kuchekar, S. Jagdale
Oct 23, 2015
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Journal
Research & Reviews: Journal of Pharmaceutics and Nanotechnology
Abstract
Norfloxacin is a synthetic fluroquinolone having wide range of antibacterial activity. It is used in treatment of systemic as well as local infections. Norfloxacin has short half-life, poor oral bioavailability and very slight solubility in water. The aim of the present work was to develop and optimize site targeted emulgel delivery of Norfloxacin for topical antibacterial activity with enhance bioavailability. The major objective was to formulate an emulgel of hydrophobic drug (Norfloxacin) and to study effect of concentration of gelling agent and emulsifiers on the system. The oil and aqueous phases were prepared separately and mixed to form emulsion. Emulsion was then mixed with gel in 1:1 proportion to form emulgel. 32 full factorial designs were used to optimize the concentration of gelling agent and emulsifier. Emulgels were evaluated for physical appearance, pH, spreadability, viscosity, drug content, in-vitro release study through cellophane and egg membrane, ex-vivo permeation study, antibacterial activity and skin irritation test. Optimized batch F4 (2% HPMC K4M and 4.2: 3.2% of Tween 80: Span 80) showed 98.81% of drug release with average flux 2.52 µg/cm 2 /min and followed Korsmeyer-Peppas kinetics. Amount of drug permeated from optimized batch F4 was 71.66 ± 2.52% with average flux 2.19 µg/cm 2 /min. Emulgel of Norfloxacin thus can