J. Kahn
1996
Citations
0
Influential Citations
5
Citations
Journal
Advances in experimental medicine and biology
Abstract
Didanosine (ddI) is a purine analog which inhibits HIV-1 replication in vitro at nM concentrations and is clinically effective for treatment of HIV-1 infection in a variety of clinical situations with diverse patient populations. Didanosine was only the second licensed antiretroviral in the USA and many other countries. All currently licenced agents, including zidovudine (ZDV), zalcitabine (ddC) and stavudine (d4T), are nucleoside analogs that inhibit HIV-1 reverse transcriptase by competitively inhibiting HIV-1 reverse transcriptase to bring about termination of nascent viral DNA synthesis. 1,2