Dihydro-beta-agarofuran sesquiterpenes and pentacyclic triterpenoids from the root bark of Osyris lanceolata.

doi:10.1021/np900597w

Paper

Dihydro-beta-agarofuran sesquiterpenes and pentacyclic triterpenoids from the root bark of Osyris lanceolata.

Published May 25, 2010 · DOI · Elizabeth M. O. Yeboah, R. Majinda, A. Kadziola

Journal of natural products

16

Citations

2

Influential Citations

Full text

Abstract

Three new dihydro-beta-agarofuran polyesters, 1alpha,9beta-difuranoyloxy-2-oxodihydro-beta-agarofuran (1), 1alpha,9beta-difuranoyloxy-2-oxo-3-enedihydro-beta-agarofuran (2), and 1alpha,9beta-difuranoyloxydihydro-beta-agarofuran (3), have been isolated from the CHCl(3) extract of the root bark of Osyris lanceolata, together with two known pentacylic triterpenoids, 4 and 5. Compounds 1-5 did not scavenge the DPPH radical within 30 min of reaction time. All five compounds displayed antifungal activity against Candida albicans. Compounds 1, 3, 4, and 5 showed antibacterial activity against the Gram-positive Bacillus subtilis and Staphylococcus aureus and Gram-negative Escherichia coli and Pseudomonas aeruginosa, with 4 and 5 being the most active. Compound 2 displayed weak antibacterial activity only against Escherichia coli.

In Vitro Study

Study Snapshot

Osyris lanceolata root bark contains five compounds with antifungal and antibacterial properties, with compounds 4 and 5 showing the most activity against bacteria.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Dihydro-beta-agarofuran sesquiterpenes and pentacyclic triterpenoids from the root bark of Osyris lanceolata.

References

Citations