C. Meese, Sabine Holzer
Mar 1, 1989
Citations
0
Influential Citations
2
Citations
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
Dimethyl 3,4,5,6-[2H4]-2-oxoheptylphosphonate (1a) was conveniently prepared in two steps from ethyl sorbate and used in a total synthesis of low-blank (⩽ 0.2% 2Ho) 16,17,18,19-[2H4]-prostaglandin D2 (2a). The required allylic alcohol 15S-8 was isolated by fractional crystallisation of the mixture of R/S epimers and then transformed to a key intermediate, 15S-silyloxy compound 10, by regiocontrolled monosilylation of diol 9.