Jun-Dan Fang, Xiao-Biao Yan, Wu-Jie Lin
Sep 11, 2019
Citations
0
Influential Citations
9
Citations
Journal
Organic letters
Abstract
A diphenyl-diselenide-mediated Claisen-type rearrangement/cyclization of propargylic aryl ethers under metal-free conditions is developed, affording various naphthofuran-2-carboxaldehydes in moderate to excellent yield. The broad substrate scope and excellent functional group compatibility suggest that it can be a straightforward and powerful method to access naphthofuran-2-carboxaldehydes in a highly regioselective manner. Moreover, this reaction can be scaled up to the gram scale.