V. Kataev, S. Meshcheryakova, E. Meshcheryakova
Jul 25, 2018
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Influential Citations
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Journal
Russian Journal of Organic Chemistry
Abstract
The reaction of 6-methylpyrimidine-2,41H,3H-dione with 2-chloromethylthiirane gave 6-methyl-N-thietan-3-ylpyrimidine-2,41H,3H-dione. Its oxidation subsequent reaction of the resulting N-1,1-dioxo-λ6-thietan-3-yl derivative with ethyl chloroacetate afforded the corresponding ethyl pyrimidinylacetate. The structure of the latter was determined by X-ray analysis, which confirmed the formation of N3-thietan-3-yl derivative rather than its N1-substituted isomer in the title reaction. According to the results of B3LYP/6-31G++d,p, PBE/3ζ, MP2/6-31G++d,p quantum chemical calculations,the N3-thietanyl derivative is more stable than the N1-isomer. It was also found that the calculated barrier to internal rotation of the thietanyl group about the N–C bond in 6-methyl-3-thietan-3-yl-pyrimidine-2,41H,3H-dione is lower than in the N1-isomer.