Discovery of 4-aminomethylphenylacetic acids as γ-secretase modulators via a scaffold design approach.

doi:10.1016/j.bmcl.2011.10.047

Paper

DOI: 10.1016/j.bmcl.2011.10.047

Discovery of 4-aminomethylphenylacetic acids as γ-secretase modulators via a scaffold design approach.

Published Dec 15, 2011 · Zhili Xin, Hairuo Peng, Andrew Zhang

Bioorganic & medicinal chemistry letters

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Study Snapshot

4-aminomethylphenylacetic acid 6q effectively reduces brain Aβ42 levels in mice and rats, showing potential as a γ-secretase modulator for Alzheimer's treatment.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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