Paper
The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors.
Published May 15, 2011 · Y. Xiang, B. Hirth, G. Asmussen
Bioorganic & medicinal chemistry letters
Q2 SJR score
57
Citations
1
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Study Snapshot
Novel benzofuran-2-carboxylic acids show potent inhibition of Pim-1 and Pim-2 enzymes, with good selectivity for the Pim kinase family.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Why target PIM1 for cancer diagnosis and treatment?
Targeting PIM1 may help in cancer diagnosis and treatment by promoting apoptosis, promoting cell proliferation, and enhancing chemotherapy response.
2010·113citations·N. Magnuson et al.·Future oncology
Future oncology
A pivotal role for Pim-1 kinase in esophageal squamous cell carcinoma involving cell apoptosis induced by reducing Akt phosphorylation.
Manipulating Pim-1 kinase may be a potential target for molecular therapy in treating esophageal squamous cell carcinoma by inducing apoptosis through reduced Akt and Bad phosphorylation and increased cleaved caspase-3/
2010·16citations·Shenglei Li et al.·Oncology reports
Oncology reports
Regulation of Skp2 Levels by the Pim-1 Protein Kinase*
Pim-1 protein kinase plays a crucial role in cell cycle regulation by regulating p27 protein levels and its ability to degrade p27, signaling S phase entry.
2010·34citations·B. Cen et al.·The Journal of Biological Chemistry
The Journal of Biological Chemistry
Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as potent, highly selective, and orally bioavailable inhibitors of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM) kinases.
Benzothienopyrimidinones show potent, highly selective, and orally bioavailable inhibition of human protooncogene PIM kinases, with potential for use in treating various hematopoietic malignancies and solid tumors.
2009·77citations·Z. Tao et al.·Journal of medicinal chemistry
Journal of medicinal chemistry
Structure-based design of 3-aryl-6-amino-triazolo[4,3-b]pyridazine inhibitors of Pim-1 kinase.
Compound 29 is a selective, soluble, and permeable inhibitor of Pim-1 kinase, improved by understanding the ATP-binding site and X-ray crystallography.
2009·54citations·Ronald L Grey et al.·Bioorganic & medicinal chemistry letters
Bioorganic & medicinal chemistry letters
Citations
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2024·3citations·Wagdy M. Eldehna et al.·Bioorganic chemistry
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Multifunctional Theranostic Probe Based on the Pim-1 Kinase Inhibitor with the Function of Tracking pH Fluctuations during Treatment.
The multifunctional theranostic reagent based on Pim-1 kinase inhibitor 5-bromobenzofuran-2-carboxylic acid can effectively track intracellular pH changes during cancer treatment, offering a promising method for cancer diagnosis and therapy.
2023·3citations·Caiyun Liu et al.·Analytical chemistry
Analytical chemistry
Anticancer therapeutic potential of benzofuran scaffolds
Benzofuran scaffolds show promising anticancer potential due to their exceptional inhibitory potency against a panel of human cancer cells compared to reference drugs.
2023·14citations·A. A. Abbas et al.·RSC Advances
RSC Advances
Bioactive Efficacy of Novel Carboxylic Acid from Halophilic Pseudomonas aeruginosa against Methicillin-Resistant Staphylococcus aureus
The novel compound HPAEtOAcE effectively inhibits MRSA growth and biofilm formation, with potential for use in antimicrobial and antibacterial treatments.
2022·6citations·Henciya Santhaseelan et al.·Metabolites
Metabolites