Effect of disodium phosphonoacetate and iododeoxyuridine on the multiplication of African swine fever virus in vitro.

doi:10.1159/000237836

Paper

Effect of disodium phosphonoacetate and iododeoxyuridine on the multiplication of African swine fever virus in vitro.

Published 1979 · C. Gil-Fernández, E. Páez, P. Vilas

Chemotherapy

Q2 SJR score

20

Citations

2

Influential Citations

Full textSemantic Scholar

Abstract

Disodium phosphonoacetate (PAA) was found to inhibit the replication of African swine fever virus (ASFV). The action of this compound has been compared with the inhibitory capacity of iododeoxyuridine (IDU) upon ASFV growing in Vero cells. The study was done by the immunofluorescence technique in order to detect formations of cytoplasmic virus antigens and inclusion bodies; both were found to be inhibited by IDU and PAA. At 100 microgram/ml, IDU blocked completely the multiplication of ASFV and with PAA, a few scattered cells showed positive fluorescence. The infectivity of the virus was reduced 1--5 log depending upon drug concentrations and time of exposure to the drugs. Inhibition of ASFV replication by PAA suggests that this virus, like other herpesviruses, involves a virus-specific DNA polymerase in its replication mechanism.

In Vitro Study

Study Snapshot

Disodium phosphonoacetate and iododeoxyuridine both inhibit African swine fever virus replication, suggesting a virus-specific DNA polymerase in its replication mechanism.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Effect of disodium phosphonoacetate and iododeoxyuridine on the multiplication of African swine fever virus in vitro.

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References

Citations

Discovery of a potent inhibitor, D-132, targeting AsfvPolX, via protein-DNA complex‐guided pharmacophore screening and in vitro molecular characterizations

D-132, a potent inhibitor targeting Asfv PolX, shows promise as a lead compound for developing innovative agents to combat African swine fever virus infections.

Cyproheptadine hydrochloride inhibits African swine fever viral replication in vitro.

Cyproheptadine hydrochloride (periactin) shows potential as a candidate drug for African swine fever prevention and treatment, inhibiting viral replication in vitro with little cytotoxicity.

Comprehensive Analysis of G-Quadruplexes in African Swine Fever Virus Genome Reveals Potential Antiviral Targets by G-Quadruplex Stabilizers

G-quadruplexes in the African swine fever virus genome can be stabilized by G4 ligands, offering potential targets for antivirals against the virus.

Identification of African Swine Fever Virus Inhibitors through High Performance Virtual Screening Using Machine Learning

Cangrelor and fostamatinib were identified as potential antiviral drugs against African swine fever virus using machine learning and optimized scoring functions for protein pocket properties.

Flavonoid Library Screening Reveals Kaempferol as a Potential Antiviral Agent Against African Swine Fever Virus

Kaempferol shows potential as an anti-ASFV agent with a distinct antiviral mechanism compared to other anti-ASFV flavonoids.