J. A. Carrillo, M. Dahl, J. Svensson
Aug 1, 1996
Citations
9
Influential Citations
123
Citations
Quality indicators
Journal
Clinical Pharmacology & Therapeutics
Abstract
Fluvoxamine is a selective serotonin reuptake inhibitor used widely in the treatment of depression and other psychiatric diseases, but little is known about the specific isozymes involved in its metabolism. This study investigated the relationship between fluvoxamine disposition and the polymorphic CYP2D6 and the polycyclic aromatic hydrocarbon (as contained in cigarette smoke) inducible CYP1A2.