Distribution and excretion of the mercury chelating agent sodium 2,3-dimercaptopropane-1-sulfonate in the rat

doi:10.1007/BF00296388

Paper

Distribution and excretion of the mercury chelating agent sodium 2,3-dimercaptopropane-1-sulfonate in the rat

Published Feb 14, 1978 · B. Gabard

Archives of Toxicology

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Abstract

SummaryThe distribution and excretion of sodium 2,3-dimercapto-1,3 14C-propane-1-sulfonate as dependent on time has been studied in the rat. The highest concentration is found in the kidneys, the lowest in the brain. The excretion is very rapid (T1/2=19 min) and follows a monoexponential curve during the first hour after administration. This holds for plasma and most of the organs too. The apparent distribution volume of the radioactivity is equivalent to the volume of the extracellular water. After oral administration, 30–40% is absorbed from the gut. The results lead to the conclusion that a fraction of the drug is weakly bound to plasma- and membrane-proteins. They are discussed with respect to the treatment of heavy metal poisoning.ZusammenfassungDie Zeitabhängigkeit der Verteilung und der Ausscheidung von Natrium-2,3-Dimercapto-1,3-14C-propan-1-Sulfonat wurde bei der Ratte untersucht. Die höchste Konzentration findet sich in den Nieren, die niedrigste im Gehirn. Die Ausscheidung ist sehr schnell (T 1/2 = 19 min) und folgt in der ersten Stunde nach der Verabreichung einer monoexponentiellen Kurve. Dies wird auch im Plasma und in den meisten Organen gefunden. Das Verteilungsvolumen der Radioaktivität ist gleich dem des extrazellulären Wassers. Nach oraler Verabreichung werden 30–40% aus dem Darm absorbiert. Die Ergebnisse führen zu der Schlußfolgerung, daß ein Teil des Chelatbildners lose an Plasma- und Membranproteine gebunden ist. Sie werden im Hinblick auf die Behandlung von Schwermetallvergiftungen diskutiert.

Study Snapshot

The mercury chelating agent sodium 2,3-dimercapto-1,3-14C-propane-1-sulfonate is rapidly distributed and excreted in the rat kidneys, with a portion weakly bound to plasma and membrane proteins, potentially impacting treatment of heavy metal poisoning.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Distribution and excretion of the mercury chelating agent sodium 2,3-dimercaptopropane-1-sulfonate in the rat

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References

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The isolated mucosal epithelium of the guinea pig small intestine has nearly identical passive permeabilities for water and thiourea, providing an optimal solution for facilitating transepthelial exchange without compromising cell integrity.

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DMPS effectively improves urinary mercury excretion in rats, with its most effective removal occurring in the kidneys, but less effective in the brain, regardless of treatment mode.

The excretion and distribution of inorganic mercury in the rat as influenced by several chelating agents

DMPS effectively increases urinary mercury excretion and lowers mercury concentrations in all organs, while the other chelating agents show different excretion patterns.

Use of unithiol for reducing radiation hazard of renal scintigraphy with chlormerodrin 203Hg. I. Estimation of the urinary excretion of 203Hg.

Unithiol administration after renal scintigraphy with chlormerodrin 203Hg significantly reduces renal irradiation by increasing urinary excretion of 203Hg by 34.85 % compared to a control group.

Totale Plasmaclearance von Na[51Cr-ÄDTA] und Inulin-14C bei Ratten

The total plasmaclearance of Na[51Cr-EDTA] and inulin-14C in healthy rats is identical, corresponding to the value of glomerular filtration rate under steady-state conditions.

Citations

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