[The distribution of 2-(dimethylamino)ethyl-(1-hydroxycyclopentyl)(phenyl)acetate in the organism of the warm-blooded animals after its intra-gastric administration].

doi:10.17116/sudmed201861236-44

Paper

[The distribution of 2-(dimethylamino)ethyl-(1-hydroxycyclopentyl)(phenyl)acetate in the organism of the warm-blooded animals after its intra-gastric administration].

Published Mar 1, 2018 · V. K. Shormanov, M. F. Pravdyuk, V. Kuzovlev

Sudebno-meditsinskaia ekspertiza

Q3 SJR score

0

Citations

0

Influential Citations

Full textSemantic Scholar

Abstract

The objective of the present study was to elucidate the distribution of 2-(dimethylamino)ethyl-(1-hydroxycyclopentyl)(phenyl)acetate in the organism of the warm-blooded animals after its intra-gastric administration. The methods applied in the study included thin layer chromatography in silicagel, aci-nitroprosalt staining reaction, UV-spectrophotometry,, and GC-mass spectrometry. The identification and the quantitation of 2-(dimethylamino)ethyl-(1-hydroxycyclopentyl)(phenyl)acetate in the organs and blood of the warm-blooded animals were carried out within 20, 150, and 360 min after a single intra-gastric administration of 1300 ml of this poisonous substance. It was shown that the largest amounts of 2-(dimethylamino)ethyl-(1-hydrpxycyclopentyl)(phenyl)acetate at the above time-points were present in the tissue of the stomach and small intestine, brain, muscles, spleen, and lungs of the animals.

Non-RCT

Animal Study

Study Snapshot

Intra-gastric administration of 2-(dimethylamino)ethyl-(1-hydroxycyclopentyl)(phenyl)acetate leads to the largest concentrations in the stomach, small intestine, brain, muscles, spleen, and lungs of warm-bloode

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

[The distribution of 2-(dimethylamino)ethyl-(1-hydroxycyclopentyl)(phenyl)acetate in the organism of the warm-blooded animals after its intra-gastric administration].

Sign up to use Study Snapshot

References

[The distribution of carbosulfan in the body of warm-blooded animals].

Carbosulfan is primarily distributed in the stomach, intestines, liver, and lungs, with its main metabolite, carbofuran, also present in these organs and spleen.

[The chemical toxicological study of cyclomed].

Cyclomed analysis can be effectively conducted using a chloroform-2-ptropanol mixture at pH 10.0, with excellent agreement in identification and quantification results.

Neonatal and Pediatric Pharmacology: Therapeutic Principles in Practice

Neonatal and pediatric pharmacology focuses on understanding and treating diseases in newborns, with special emphasis on preventing neonatal infections and promoting lung development.

Acute progressive midbrain hemorrhage after topical ocular cyclopentolate administration.

Topical ocular cyclopentolate administration can cause midbrain hemorrhage, leading to death in a 55-year-old male.

Citations