Paper
Disulfide bonds as switches for protein function.
Published Apr 1, 2003 · P. Hogg
Trends in biochemical sciences
Q1 SJR score
544
Citations
10
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Highly CitedStudy Snapshot
Disulfide bonds can be switches for protein function, controlling the activity of secreted soluble proteins and cell-surface receptors through specific cleavage reactions.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Redox control on the cell surface: implications for HIV-1 entry.
Disulfide bonds in CD4 and gp120 proteins play a crucial role in HIV-1 entry, with redox changes in these bonds playing a crucial role in HIV-1 entry.
2003·48citations·L. Matthias et al.·Antioxidants & redox signaling
Antioxidants & redox signaling
Protein-disulfide Isomerase-mediated Reduction of Two Disulfide Bonds of HIV Envelope Glycoprotein 120 Occurs Post-CXCR4 Binding and Is Required for Fusion*
Two disulfide bonds in HIV envelope glycoprotein 120 are reduced during lymphocyte-cell interaction after CXCR4 binding, triggering HIV/cell fusion.
2003·153citations·R. Barbouche et al.·The Journal of Biological Chemistry
The Journal of Biological Chemistry
Inhibitors of Protein-Disulfide Isomerase Prevent Cleavage of Disulfide Bonds in Receptor-bound Glycoprotein 120 and Prevent HIV-1 Entry*
Inhibitors of protein-disulfide isomerase (PDI) prevent HIV-1 entry by preventing disulfide reduction in receptor-bound glycoprotein 120, offering new potential targets for anti-HIV agents.
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The Journal of Biological Chemistry
The von Willebrand factor-reducing activity of thrombospondin-1 is located in the calcium-binding/C-terminal sequence and requires a free thiol at position 974.
The von Willebrand factor-reducing activity of thrombospondin-1 is located in the calcium-binding/C-terminal sequence and requires a free thiol at position 974.
2002·33citations·J. Pimanda et al.·Blood
Blood
Sustained integrin ligation involves extracellular free sulfhydryls and enzymatically catalyzed disulfide exchange.
Sustained integrin ligation on platelets depends on extracellular free sulfhydryls and enzymatically catalyzed disulfide exchange, while agonist-induced platelet stimulation is independent of ecto-sulfhydryls.
2002·206citations·J. Lahav et al.·Blood
Blood
Citations
Conformational activation and disulfide exchange in HIV-1 Env induce cell-free lytic/fusogenic transformation and enhance infection.
Conformational activation and disulfide exchange in HIV-1 Env can induce and enhance fusion transformations, potentially aiding in the development of novel preventative strategies against HIV entry.
2025·0citations·C. Ang et al.·Journal of virology
Journal of virology
Mechanism and Application of Biomaterials Targeting Reactive Oxygen Species and Macrophages in Inflammation
Biomaterials targeting reactive oxygen species and macrophages can effectively reduce inflammation, potentially preventing and delaying chronic diseases like diabetes, cancer, arthritis, and inflammatory bowel disease.
2024·0citations·Mengxuan Yu et al.·International Journal of Molecular Sciences
International Journal of Molecular Sciences
Cold Atmospheric Plasma: Possible Cure of Autoimmune Disorders and Cancer via Attenuating Inflammation
Cold atmospheric plasma (CAP) may be a potential cure for autoimmune disorders and cancers by attenuating prolonged inflammation through maintaining mitochondrial reduction-oxidation homeostasis.
2024·0citations·Xiaofeng Dai et al.·International Journal of Biological Sciences
International Journal of Biological Sciences
Core and valence photoelectron spectroscopy of a series of substituted disulfides.
Photoelectron spectroscopy can effectively estimate the C-S-S-C dihedral angle in substituted disulfides, providing a site-specific probe of hydrogen bonding.
2024·0citations·H. McGhee et al.·The Journal of chemical physics
The Journal of chemical physics
Mechanisms and therapeutic potential of disulphidptosis in cancer
Disulphidptosis, a novel cell death mechanism, offers novel insights and innovative cancer treatment strategies, offering potential for other diseases.
2024·2citations·Yanhu Li et al.·Cell Proliferation
Cell Proliferation
Research Progress on the Mechanism of the Impact of Myofibrillar Protein Oxidation on the Flavor of Meat Products
Myofibrillar protein oxidation significantly impacts the sensory quality of meat products, including flavor, taste, and color, and controlling this process is crucial for meat processing and quality control.
2024·1citation·Lingping Zhang et al.·Foods
Foods
Enhanced control of RNA modification and CRISPR-Cas activity through redox-triggered disulfide cleavage.
This study presents a strategy using cyclic disulfide-substituted acylating agents to control gene editing in cells through conditional control of CRISPR-Cas systems, offering precise in vivo control for targeted applications.
2024·0citations·Huajun Lei et al.·Bioorganic & medicinal chemistry
Bioorganic & medicinal chemistry