Disulfide-Catalyzed Iodination of Electron-Rich Aromatic Compounds.

doi:10.1021/acs.joc.9b00769

Paper

DOI: 10.1021/acs.joc.9b00769

Disulfide-Catalyzed Iodination of Electron-Rich Aromatic Compounds.

Published Apr 25, 2019 · Keisuke Iida, Shunsuke Ishida, Takamichi Watanabe

The Journal of organic chemistry

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Abstract

Herein, a disulfide-catalyzed electrophilic iodination of aromatic compounds using 1,3-diiodo-5,5-dimethylhydantoin (DIH) has been developed. The disulfide activates DIH as a Lewis base to promote the iodination reaction in acetonitrile under mild conditions. This system is applicable to a wide range of electron-rich aromatic compounds, including acetanilide, anisole, imidazole, and pyrazole derivatives.

Study Snapshot

Disulfide-catalyzed electrophilic iodination of aromatic compounds using 1,3-diiodo-5,5-dimethylhydantoin (DIH) is a versatile method for preparing various aromatic compounds under mild conditions.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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