Yunfei Du, Goutham Kommuru, Jingran Zhang
Apr 18, 2022
Citations
0
Influential Citations
0
Citations
Journal
Synlett
Abstract
A divergent synthesis of isobenzofuran-1(3H)-one and 3,4-dihydroisochroman-1-one derivatives has been realized from the reaction of o-alkenyl benzoic acids/amides with PhICl2 and diphenyl disulfides/diselenides. Depending on the substitution type of o-alkenyl benzoic acids and amides, this metal-free intramolecular oxychalcogenation approach regioselectively affords isobenzofuran-1(3H)-ones or 3,4-dihydroisochroman-1-ones, via 5-exo-trig or 6-endo-trig cyclization processes, respectively.