The Docosatriene Protectin D1 Is Produced by TH2 Skewing and Promotes Human T Cell Apoptosis via Lipid Raft Clustering*

doi:10.1074/jbc.M509796200

Paper

The Docosatriene Protectin D1 Is Produced by TH2 Skewing and Promotes Human T Cell Apoptosis via Lipid Raft Clustering*

Published Dec 30, 2005 · A. Ariel, Pin Li, Wei Wang

Journal of Biological Chemistry

Q1 SJR score

240

Citations

8

Influential Citations

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Abstract

Docosahexaenoic acid, a major ω-3 fatty acid in human brain, synapses, retina, and other neural tissues, displays beneficial actions in neuronal development, cancer, and inflammatory diseases by mechanisms that remain to be elucidated. In this study we found, using lipid mediator informatics employing liquid chromatography-tandem mass spectrometry, that (10,17S)-docosatriene/neuroprotectin D1, now termed protectin D1 (PD1), is generated from docosahexaenoic acid by T helper type 2-skewed peripheral blood mononuclear cells in a lipoxygenase-dependent manner. PD1 blocked T cell migration in vivo, inhibited tumor necrosis factor α and interferon-γ secretion, and promoted apoptosis mediated by raft clustering. These results demonstrated novel anti-inflammatory roles for PD1 in regulating events associated with inflammation and resolution.

In Vitro Study

Highly Cited

Study Snapshot

Protectin D1 (PD1), a docosahexaenoic acid-derived molecule, plays a novel anti-inflammatory role by blocking T cell migration, inhibiting inflammation, and promoting apoptosis through lipid raft clustering.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

The Docosatriene Protectin D1 Is Produced by TH2 Skewing and Promotes Human T Cell Apoptosis via Lipid Raft Clustering*

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References

A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease.

NPD1 promotes brain cell survival by inducing antiapoptotic and neuroprotective gene-expression programs that suppress Abeta42-induced neurotoxicity in Alzheimer's disease.

A Role for the Mouse 12/15-Lipoxygenase Pathway in Promoting Epithelial Wound Healing and Host Defense*

The mouse 12/15-lipoxygenase pathway plays a novel role in wound healing and host defense, promoting epithelial wound repair and preserving tissue function in the eye.

Dietary n-3 polyunsaturated fatty acids promote activation-induced cell death in Th1-polarized murine CD4+ T-cells Published, JLR Papers in Press, May 16, 2004. DOI 10.1194/jlr.M400028-JLR200

Dietary n-3 PUFAs promote activation-induced cell death in proinflammatory Th1 cells, potentially due to alterations in membrane microdomain fatty acid composition.

Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress.

Neuroprotectin D1 protects retinal pigment epithelial cells from oxidative stress-induced apoptosis, potentially contributing to photoreceptor cell survival in retinal degenerations.

Novel Docosanoids Inhibit Brain Ischemia-Reperfusion-mediated Leukocyte Infiltration and Pro-inflammatory Gene Expression*

Novel docosanoids, such as 10,17S-docosatriene, can counteract leukocyte-mediated injury and pro-inflammatory gene induction in ischemic stroke, offering neuroprotection.

Citations

The potential role of n-3 fatty acids and their lipid mediators on asthmatic airway inflammation

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How membrane phospholipids containing long chain polyunsaturated fatty acids and their oxidation products orchestrate lipid raft dynamics to control inflammation.

Select LC-PUFA acyl chains and oxidized acyl chains of phospholipids control lipid raft dynamics and inflammation in myeloid and lymphoid cells.

Immunomodulation of periodontitis with SPMs

SPMs can effectively modulate inflammation in periodontal disease by reversing the inflammatory process and promoting oral microbiome balance.

n-3 Polyunsaturated Fatty Acids Modulate LPS-Induced ARDS and the Lung–Brain Axis of Communication in Wild-Type versus Fat-1 Mice Genetically Modified for Leukotriene B4 Receptor 1 or Chemerin Receptor 23 Knockout

Omega-3 polyunsaturated fatty acids and RvE1 receptor deficiency affect lung-brain communication during ARDS by altering inflammatory and lipid mediator profiles and glial activity markers.

The Optimum Dietary Phenylalanine Requirement of Hybrid Grouper (Epinephelusfuscoguttatus ♀ × Epinepheluslanceolatus ♂) Juveniles: Effects on Growth Performance, Gut Micromorphology, and Antioxidation

Optimal phenylalanine content in hybrid grouper juveniles' diets is 12.7 g/kg, which enhances growth performance, feed utilization, gut micromorphology, and immunity.

Endogenous inhibitory mechanisms in asthma

Endogenous inhibitory mechanisms, such as steroid hormones and regulatory T cells, play a promising role in asthma resolution, tissue repair, and homeostasis, offering potential targets for prevention and treatment.