Yibin Ye, Kelvin Pak Shing Cheung, Lisi He
May 1, 2018
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Influential Citations
14
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Journal
Organic chemistry frontiers
Abstract
By employing easily accessible 2-alkynylanilines and the well-established fluoroform-derived CuCF3 reagent, a novel class of 3-(trifluoromethyl)indoles can be synthesized in good yields with no ambiguity of the CF3 position. The method utilizes a domino cyclization/trifluoromethylation strategy to construct the indole cores with the concomitant installation of the CF3 group. The ultimate source of CF3 is the low-cost industrial by-product fluoroform (CF3H).