E. Rogers, R. L. Clark, H. J. Becker
Nov 1, 1964
Citations
0
Influential Citations
18
Citations
Journal
Proceedings of the Society for Experimental Biology and Medicine
Abstract
Summary 1. Preparations of the 4-amino, 4-acetamido and 4-benzamido derivatives of methyl-2-ethoxybenzoate and of 4-amino-2-ethylaminobenzoic acid are reported. 2. Anti-coccidial activity is demonstrated for 2-substituted PABAs, especially those containing 2-alkoxy, alkythio and alkylamino groups. 3. The most potent compounds are 4-amino-2-ethoxybenzoic acid and its ester and N-acyl derivatives. The authors gratefully acknowledge the help of Mr. J. L. Ciminera in designing the statistical procedure used in the bio assay.