Paper
The effect of 2'-fluoro-2'-deoxycytidine on herpes virus growth.
Published Mar 20, 1985 · F. Wohlrab, A. T. Jamieson, J. Hay
Biochimica et biophysica acta
UNKNOWN SJR score
30
Citations
2
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
In Vitro StudyStudy Snapshot
2'-fluoro-2'-deoxycytidine (dCfl) shows considerable anti-viral activity against herpes viruses, with comparable effects to araC and more efficient than br 5 dC, but less so than acyclovir.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
2'-Fluoro-2'-deoxycytidine triphosphate as a substrate for RNA- and DNA-dependent DNA polymerases.
2′-fluoro-2′-deoxycytidine triphosphate (dCflTP) is a substrate for RNA- and DNA-dependent DNA polymerases, with aphidicolin acting as a noncompetitive inhibitor.
1985·9citations·H. Aoyama et al.·Biochimica et biophysica acta
Biochimica et biophysica acta
Specific interaction of netropsin, distamycin-3 and analogs with LC duplexes: reversion towards the B form of the 2'-deoxy-.2'-deoxy-2'-fluoro-hybrid duplexes upon specific interaction with netropsin, distamycin-3 and analogs.
The specific interaction of netropsin and distamycin-3 with LC duplexes involves a B-type transition in the fluorine-carrying strand, with the geometry of the pyrimidine strand being crucial for the specific interaction.
1982·17citations·C. Marck et al.·Nucleic acids research
Nucleic acids research
Template activity of poly(2'-fluoro-2'-deoxyinosinic acid) for murine leukemia virus reverse transcriptase.
Poly(2′-fluoro-2′-deoxyinosinic acid) effectively serves as a template for murine leukemia virus reverse transcriptase, while the parent compound shows little or no activity.
1982·3citations·T. Fukui et al.·Cancer letters
Cancer letters
The crystal structures of 2'-deoxy-2'-fluorocytidine and 2'-deoxy-2'-fluorouridine
The crystal structures of 2'-deoxy-2'-fluoronucleosides reveal similar molecular conformations to cytidine, with dCfl showing a similar orientation and dUfl showing an unusual sugar puckering.
1982·22citations·C. Marck et al.·Journal of Molecular Structure
Journal of Molecular Structure
Differential stabilization by netropsin of inducible B-like conformations in deoxyribo-, ribo- and 2'-deoxy-2'-fluororibo-adenosine containing duplexes of (dA)n . (dT)n and (dA)n . (dU)na.
The A to B transition in DNA is facilitated by fluorine substitution in the sugar moiety, while the 2'-OH group greatly limits this conformational change.
1982·26citations·C. Zimmer et al.·Nucleic acids research
Nucleic acids research
Polynucleotide helix geometry and stability. Spectroscopic, antigenic and interferon-inducing properties of deoxyribose-, ribose-, or 2'-deoxy-2'-fluororibose-containing duplexes of poly(inosinic acid) . poly(cytidylic acid).
Substituting one or both strands with 2'-fluororibose does little to alter the structure of (rI)n. (rC)n, while deoxyribose substitution significantly changes the helix's structure.
1982·24citations·N. Kakiuchi et al.·The Journal of biological chemistry
The Journal of biological chemistry
The crystal and molecular structure of 2'-deoxy-2'-fluoroinosine monohydrate.
The crystal structure of 2'-deoxy-2'-fluoroinosine monohydrate reveals a twisted conformation in the sugar ring pucker, suggesting it may be a characteristic feature of 2'-fluoronucleosides.
1981·24citations·T. Hakoshima et al.·Nucleic acids research
Nucleic acids research
Nucleoside conformation is determined by the electronegativity of the sugar substituent.
The electronegativity of the sugar substituent determines nucleoside conformation, which may be the principal force determining the differences between DNA and RNA.
1980·169citations·W. Guschlbauer et al.·Nucleic acids research
Nucleic acids research
Thymidylate synthetase from Escherichia coli K12. Purification, and dependence of kinetic properties on sugar conformation and size of the 2' substituent.
Thymidylate synthetase from Escherichia coli K12 has a recognition mechanism for nucleotides with sugar moiety in the 2'-endo-3'-exo conformation, supporting its role in nucleotide synthesis.
1979·23citations·T. Haertlé et al.·European journal of biochemistry
European journal of biochemistry
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