The stimulus effect of 5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline is similar to that of cocaine but different from that of amphetamine

doi:10.1016/S0091-3057(01)00666-9

Paper

DOI: 10.1016/S0091-3057(01)00666-9

The stimulus effect of 5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline is similar to that of cocaine but different from that of amphetamine

Published Feb 28, 2002 · R. Young, R. Glennon

Pharmacology Biochemistry and Behavior

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Study Snapshot

TDIQ shows potential as a pharmacotherapy for cocaine dependence by distinguishing between stimuli produced by amphetamine, methylphenidate, ephedrine, and cocaine.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Citations

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The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The "Phenylalkylaminome" with a Focus on Selected Drugs of Abuse.

Phenylalkylamines, particularly phenylethylamine, play a complex and interwoven role in the actions of drugs of abuse, with receptors and monoamine transporters playing key roles in their actions.

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TDIQ (5,6,7,8-tetrahydro-1,3-dioxolo [4,5-g]isoquinoline): discovery, pharmacological effects, and therapeutic potential.

TDIQ shows potential as a new treatment for anxiety and obesity with a favorable ratio of therapeutic effects to side effects, offering a potential new approach to alpha(2)-adrenergic receptor selective drugs.

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TDIQ (5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline) inhibits the consumption of “snacks” in mice

TDIQ is a potent appetite suppressant with a favorable therapeutic-like effect to side effect-like ratio, offering a potential new treatment for obesity.

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TDIQ (5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline) exhibits anxiolytic-like activity in a marble-burying assay in mice

TDIQ shows anxiolytic-like activity in mice without disrupting motor activities, making it a potential lead candidate for treating certain forms of anxiety without significant side effects.

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Further characterization of the stimulus properties of 5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline

TDIQ produces distinct stimulus effects from other phenylalkylamines, and its analogs may serve as a novel class of phenylalkylamines with unique stimulus properties.

2002·9citations·R. Glennon et al.·Pharmacology Biochemistry and Behavior

Pharmacology Biochemistry and Behavior