Therapeutic effect of a novel anilidoquinoline derivative, 2-(2-methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide, in Japanese encephalitis: correlation with in vitro neuroprotection.

doi:10.1016/j.ijantimicag.2008.05.001

Paper

Therapeutic effect of a novel anilidoquinoline derivative, 2-(2-methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide, in Japanese encephalitis: correlation with in vitro neuroprotection.

Published Oct 1, 2008 · Joydeep Ghosh, V. Swarup, A. Saxena

International journal of antimicrobial agents

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Abstract

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In Vitro Study

Study Snapshot

The novel anilidoquinoline derivative, 2-(2-Methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide, significantly decreases viral load and increases survival in mice with Japanese encephalitis.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Therapeutic effect of a novel anilidoquinoline derivative, 2-(2-methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide, in Japanese encephalitis: correlation with in vitro neuroprotection.

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References

Citations

A novel strategy for catalyzing the functionalization of C(sp3)-H in 2- methylquinoline derivatives using amino acids

Amino acids, particularly L-leucine, significantly improve the efficiency of functionalizing C(sp3)-H in 2-methylquinoline derivatives, resulting in a 91.47 percent yield of 1-(4-nitrophenyl)-2-(quinoline-2-yl)ethane-1-

Recent Advances in Antivirals for Japanese Encephalitis Virus

Antivirals targeting both the Japanese encephalitis virus and host factors show promise in treating JE effectively, but a clinically specific drug is needed.

N-Arylation of 3-Formylquinolin-2(1H)-ones Using Copper(II)-Catalyzed Chan–Lam Coupling

Copper-catalyzed Chan-Lam coupling allows for the synthesis of 32 new N-aryl-3-formyl-2-quinolone derivatives, useful building blocks for various biological activities.

Synthesis, spectral characterization, crystal structure and computational investigation of 2-formyl-6-methoxy-3-carbethoxy quinoline as potential SARS-CoV inhibitor

2F6M3CQ shows potential as a SARS-CoV inhibitor due to its good binding energy and drug-like properties, making it a promising candidate for COVID-19 treatment.

Effect of electron donors on the photophysical and theoretical properties of BODIPY dyes based on tetrazolo[1,5-a]quinoline

Tetrazolo[1,5-a] quinoline-based BODIPY dyes show potential for water detection systems due to their fluorescence quantum yield, stability, and aggregation-induced emission characteristics.

Synthesis, structural characterization, in vitro comparative DNA/RNA binding, and computational studies of half-sandwich Ru (II)(ƞ6-p-cymene) aminoquinoline complex

The half-sandwich Ru (II)(6-p-cymene) aminoquinoline complex 1 shows a stronger binding affinity towards ct-DNA, cleaves tRNA, and exhibits low cytotoxicity against human cancer cell lines.

Spectroscopic profiling, DFT computations, molecular docking and molecular dynamic simulation of biologically active 5-isoquinolinesulfonic acid

5IQSA shows potential as a biologically active compound with potential for drug discovery and development.

Biocatalytic one pot three component approach: Facile synthesis, characterization, molecular modelling and hypoglycemic studies of new thiazolidinedione festooned quinoline analogues catalyzed by alkaline protease from Aspergillus niger.

The novel ANAP-catalyzed one-pot approach successfully synthesized new thiazolidinedione festooned quinoline analogues with promising hypoglycemic activity, comparable to pioglitazone and rosiglitazone.

Molecular structure spectroscopic Elucidation, IEFPCM solvation (UV–Vis, MEP, FMO, NBO, NLO), molecular docking and biological assessment studies of lepidine (4-Methylquinoline)

Lepidine, a 4-methylquinoline compound, shows promising biological activities and potential pharmaceutical applications, with excellent natural bond orbital properties and kinetic stability and reactivity.