Paper
Selective antilipolytic effect of bacitracin in the isolated fat cell.
Published Sep 16, 1982 · C. Heckemeyer, S. Solomon, J. Barker
Biochemical and biophysical research communications
Q1 SJR score
8
Citations
0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
In Vitro StudyStudy Snapshot
Bacitracin inhibits lipolysis in isolated fat cells, allowing for study of antilipolysis without stimulating glucose uptake.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
Sign up to use Study Snapshot
Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.
Full text analysis coming soon...
References
Bacitracin: an inhibitor of the insulin degrading activity of glutathione-insulin transhydrogenase.
Bacitracin inhibits the insulin degrading activity of glutathione-insulin transhydrogenase, potentially explaining its inhibitory effects on insulin degradation by target cells.
1981·102citations·R. Roth·Biochemical and biophysical research communications
Biochemical and biophysical research communications
Binding, internalization, and lysosomal association of 125I-glucagon in isolated rat hepatocytes. A quantitative electron microscope autoradiographic study.
Binding, internalization, and lysosomal association of 125I-glucagon in rat hepatocytes is a general process related to many polypeptide hormones and growth factors, potentially mediating degradation and loss of surface receptors.
1980·53citations·P. Barazzone et al.·The Journal of clinical investigation
The Journal of clinical investigation
Time-course of insulin degradation in perifused isolated rat adipose cells.
Insulin degradation in isolated rat adipose cells occurs at 37 degrees C, with a first-order rate constant of 0.023 +/- 0.004 min-1, and shows antilipolytic activity on epinephrine-stimulated lipolysis.
1980·25citations·C. Huber et al.·The Journal of clinical investigation
The Journal of clinical investigation
Lysosomal association of internalized 125I-insulin in isolated rat hepatocytes. Direct demonstration by quantitative electron microscopic autoradiography.
Insulin in isolated rat hepatocytes initially localizes to the plasma membrane, is progressively internalized, and preferentially associates with lysosomal structures, potentially linking cell surface binding to insulin degradation and receptor loss.
1979·129citations·J. Carpentier et al.·The Journal of clinical investigation
The Journal of clinical investigation
Binding and receptor-mediated degradation of insulin in adipocytes.
Receptor-mediated insulin degradation occurs in adipocytes, with half of bound (iodo) insulin molecules degraded and the other half dissociating in intact form at any receptor occupancy.
1978·155citations·J. Gliemann et al.·The Journal of biological chemistry
The Journal of biological chemistry
Citations
Enzyme destruction by a protease contaminant in bacitracin.
Bacitracin may contain a protease enzyme, affecting enzyme inhibitory results, so it's important to test for contamination before using it.
2000·23citations·S. Rogelj et al.·Biochemical and biophysical research communications
Biochemical and biophysical research communications
Insulin degradation: progress and potential.
Insulin degradation plays a complex role in controlling insulin action, with potential for direct intracellular interaction with IDE to modulate protein and fat metabolism.
1998·854citations·W. Duckworth et al.·Endocrine reviews
Endocrine reviews
Equilibrium binding of insulin to rat white fat cells at 15 degrees C.
Insulin binding to rat epididymal fat cells at 15 degrees C is highly specific, with 99.7% of binding sites described by a simple binding isotherm and less than 0.3% having higher affinity.
1986·9citations·E. Lipkin et al.·The Journal of biological chemistry
The Journal of biological chemistry
Bacitracin enhances intracellular accumulation of insulin in rat adipocytes.
Bacitracin increases intracellular insulin accumulation in rat adipocytes and inhibits its intracellular degradation, suggesting its potential role in insulin secretion.
1985·5citations·P. Lönnroth et al.·Biochimica et biophysica acta
Biochimica et biophysica acta
Evidence that Bacitracin Alters Intracellular Insulin Metabolism in Isolated Rat Hepatocytes
Bacitracin significantly affects hepatocyte insulin metabolism, suggesting that its continued use in studies of hepatocyte-insulin interaction should be avoided.
1985·28citations·D. Peavy et al.·Diabetes
Diabetes