The influence of Con A on human neutrophils adhesion in interactions with sepharose 4B, C3b-sephadex G-25, DEAE-sephadex A-25, polymethylmethacrylate was studied. In concentrations 25 mg/ml and more Con A completely inhibited IgG-dependent adhesion but had no influence on other types of adhesion reactions. The effect was due to Con A interaction with neutrophils and could not be reproduced by Con A pretreatment of IgG-sepharose. Results are considered to be a manifestation of lectin-dependent modulation of cell receptors functions.

Concanavalin A (Con A) completely inhibits IgG-dependent adhesion of human neutrophils, demonstrating lectin-dependent modulation of cell receptor functions.

Effect of concanavalin a on different types of adhesive reactions of human neutrophils

Key Takeaway: Concanavalin A (Con A) completely inhibits IgG-dependent adhesion of human neutrophils, demonstrating lectin-dependent modulation of cell receptor functions.