Effect of dibutyryl cyclic adenosine 3',5'-monophosphate, theophylline, and other nucleotides upon calcium and phosphate metabolism.

doi:10.1172/JCI105874

Paper

Effect of dibutyryl cyclic adenosine 3',5'-monophosphate, theophylline, and other nucleotides upon calcium and phosphate metabolism.

Published Aug 1, 1968 · H. Rasmussen, M. Pechet, D. Fast

The Journal of clinical investigation

Q1 SJR score

93

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1

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Abstract

The effect of dibutyryl cyclic adenosine 3',5'-monophosphate upon calcium and phosphate metabolism in thyroparathyroidectomized rats was undertaken in an effort to clarify the possible role of adenosine 3',5'-monophosphate (3',5' AMP) in parathyroid hormone action. The infusion of dibutyryl cyclic 3',5' AMP at a rate of 3 mg/hr into thyroparathyroidectomized rats leads to changes in calcium, phosphate, and hydroxyproline excretion, and calcium and phosphate concentrations in plasma that are qualitatively similar to those induced by parathyroid hormone given at a rate of 5 mug/hr. The effect of dibutyryl cyclic 3',5' AMP upon calcium and hydroxyproline mobilization from bone is blocked by thyrocalcitonin administration in the same way that thyrocalcitonin blocks PTH effects. Other closely related nucleotides do not act in the same way. These data indicate that dibutyryl cyclic 3',5' AMP produces effects similar to parathyroid hormone in thyroparathyroidectomized rats, and support the notion that 3',5' AMP is an intermediate in the mechanism of PTH action. However, the changes in magnesium and potassium excretion are different after dibutyryl cyclic 3',5' AMP infusion from those seen after PTH infusion. Also, theophylline was found to potentiate the action of smaller doses of dibutyryl 3',5' AMP, but not that of PTH.

Non-RCT

Animal Study

Highly Cited

Study Snapshot

Dibutyryl cyclic adenosine 3',5'-monophosphate (DiCAMP) acts similarly to parathyroid hormone in thyroparathyroidectomized rats, suggesting it may be an intermediate in the mechanism of parathyroid hormone action.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Effect of dibutyryl cyclic adenosine 3',5'-monophosphate, theophylline, and other nucleotides upon calcium and phosphate metabolism.

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References

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Adrenocorticotropic hormone (ACTH) stimulates adrenal steroidogenesis by increasing cyclic AMP levels, which may play a role in restoring adrenal growth and steroidogenic capacity after hypophysectomy.

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Porcine thyrocalcitonin has been isolated, and its relationship with the TAR peptide remains unclear.

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Estrogen's acute elevation of adenosine 3',5'-monophosphate in the rat uterus precedes its significant influence on uterine metabolism.

Citations

Cyclic adenosine monophosphate in acute ischemic stroke: some to update, more to explore

Elevating cAMP levels in the brain after ischemic stroke can reduce neuroinflammation and improve neurological function, making it a potential new therapeutic strategy for acute ischemic stroke.

New perspectives in signaling mediated by receptors coupled to stimulatory G protein: the emerging significance of cAMP eﬄux and extracellular cAMP-adenosine pathway

CAMP efflux and the extracellular cAMP-adenosine pathway play a crucial role in regulating GsPCR-induced cell responses in various cell types.

α2 adrenoreceptor agonist regulates protein kinase C‐induced heat shock protein 27 phosphorylation in C6 glioma cells

Dexmedetomidine may have neuroprotective effects by regulating heat shock protein 27 phosphorylation in C6 glioma cells, potentially through PKC activation.

Adenylyl cyclase‐cAMP system inhibits thrombin‐induced HSP27 in vascular smooth muscle cells

The adenylyl cyclase-cAMP system inhibits thrombin-induced HSP27 induction in aortic smooth muscle cells, potentially affecting the thrombin-induced PKC-p38 MAP kinase signaling pathway.

Effect of age on the response to parathyroid hormone.

The phosphaturic response to parathyroid hormone is age-dependent, with a greater decrease of TP/GF in children than in adults.

Functional asymmetry in phosphate transport and its regulation in opossum kidney cells: parathyroid hormone inhibition

In opossum kidney cells, only apical Na/Pi co-transport is sensitive to PTH inhibition, suggesting PTH receptor properties may differ between apical and basolateral surfaces.

Parathyroid hormone regulation of Na+/H+ exchange in opossum kidney cells: polarity and mechanisms

Parathyroid hormone partially inhibits Na+/H+ exchange in opossum kidney cells, with receptors at both apical and basolateral cell surfaces.

A dual mechanism for regulation of kidney phosphate transport by parathyroid hormone.

PTH regulates kidney phosphate transport by interacting with two classes of receptors and transmembrane-signaling mechanisms, with physiological levels regulating phosphate transport through protein kinase c and higher concentrations activating adenylate cyclase.

Theophylline-induced hypercalcemia.

Theophylline-induced hypercalcemia can be reversed by propranolol, suggesting that beta-adrenergic regulation plays a role in this process.