The Effect of Flunixin Injection on Reproductive Hormones in Male Mice

doi:10.19026/IJAVA.6.5620

Paper

The Effect of Flunixin Injection on Reproductive Hormones in Male Mice

Published Apr 20, 2014 · I. Kazemi, M. Modaresi, A. Pirestani

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Abstract

Flunixin is an anti inflammatory non steroidal chemical compound which is used as an analgesic and antipyretic drug in veterinary. Considering the frequent use of this drug in recent years this study was conducted to investigate the effects of this drug on pituitary-gonad axis of male mice. Results of this study can be used highly for better use of this drug and saving sexual power of male sex. Five experimental groups with eight male mice in each group were studied as control, Placebo and three treatment groups. Flunixin was injected in 0.5, 1 and 1.5 mg/kg in peritoneum in a twenty-day period. Control group didn't receive any injection and Placebo group received only physiological serum. At the end of twenty days, blood samples were prepared and the amounts of FSH, LH and testosterone hormones were measured. Obtained data were analyzed using SPSS11.5 program. According to results, FSH and LH concentrations were increased significantly (p<0.05) but testosterone was not changed. Results show that flunixin can affect sexual power of male sex by increasing hormones of pituitary-testicle axis.

RCT

Animal Study

Study Snapshot

Flunixin injections significantly increase FSH and LH concentrations in male mice, but do not affect testosterone levels, affecting their sexual power.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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The Effect of Flunixin Injection on Reproductive Hormones in Male Mice

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