Paper
[The effect of gancao on glucocorticoid receptors in chronic obstructive pulmonary disease].
Published Oct 1, 1999 · T. Liu, B. Wang, X. Wang
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
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Abstract
OBJECTIVE To study the effect of gancao and glucocorticoid on glucocorticoid receptors. METHODS The number of GCR of peripheral blood leukocytes was determined and FEV1% was assessed in 45 COPD patients and 10 control subjects. RESULTS GCR was significantly lower in COPD patients during acute attack than in control subjects while F and ACTH were significantly higher (P < 0.001). In gancao, glucocorticoid and combination of gancao and glucocorticoid treated groups FEV1% was higher after treatment, especially in the combination group(P < 0.001). Gancao induced up-regulation of GCR while glucocorticoid induced down-regulation of GCR, but combination of gancao and glucocorticoid had no effect on GCR. CONCLUSIONS Gancao might reverse the down-regulation of glucocorticoid on GCR, thus enhance and prolong the effects of glucocorticoids.
Non-RCTGancao may enhance and prolong the effects of glucocorticoids in COPD patients by reversing the down-regulation of glucocorticoid receptors.
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