Paper
Direct effect of phenylethylamine upon isolated rat aortic strip.
Published May 2, 1980 · T. R. Hansen, J. Greenberg, A. Mosnaim
European journal of pharmacology
Q1 SJR score
22
Citations
0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
In Vitro StudyStudy Snapshot
Phenylethylamine directly stimulates vascular smooth muscle in isolated rat aortic strips, with phentolamine and propranolol altering but not blocking this response.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Phenylethylamine hypothesis of affective behavior.
PEA deficits in the brain may contribute to a large percentage of endogenous depressions, and increasing PEA levels may partially explain the elation induced by marijuana and the therapeutic action of antidepressant agents.
2015·156citations·H. Sabelli et al.·The American journal of psychiatry
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Insulin-dependent diabetics show a significant reduction in blood platelets' monoamine oxidase activity, potentially indicating a role for the MAO/monoamine system in diabetes pathophysiology.
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Structure activity relationships between catecholamines and the alpha-adrenergic receptor responsible for the aggregation of human platelets by epinephrine.
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Method for the rapid determination of norepinephrine, dopamine, and serotonin in the same brain region
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Pharmacology Biochemistry and Behavior
Preliminary studies of the sodium borohydride stabilizable binding of phenylethylamine and tyramine to brain preparations.
Phenylethylamine and tyramine show higher binding to brain preparations than tryptamine, with dopamine and D-amphetamine decreasing this binding.
1978·9citations·F. Ungar et al.·Research communications in chemical pathology and pharmacology
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Citations
Spasmolytic Effects of Aphanizomenon Flos Aquae (AFA) Extract on the Human Colon Contractility
Klamin® reduces human colon contractility through -PEA, which activates neural TAAR1 and induces serotonin release from serotoninergic neurons in the myenteric plexus.
2021·4citations·A. Amato et al.·Nutrients
Nutrients
Dual excitatory and smooth muscle‐relaxant effect of β‐phenylethylamine on gastric fundus strips in rats
PEA has dual contractile and relaxant effects on rat gastric fundus, with the contractile effect likely involving 5HT receptors and the relaxant effect likely involving TAAR1.
2018·5citations·F. Batista-Lima et al.·Clinical and Experimental Pharmacology and Physiology
Clinical and Experimental Pharmacology and Physiology
Behavioral Effects of &bgr;-Phenylethylamine and Various Monomethylated and Monohalogenated Analogs in Mice Are Mediated by Catecholaminergic Mechanisms
&bgr;-phenylethylamine and its methylated and para-halogenated analogs can increase or decrease mouse behavior, with &agr;-MePEA being the most potent.
2015·6citations·A. Mosnaim et al.·American Journal of Therapeutics
American Journal of Therapeutics
Modulation of Resistance Artery Tone by the Trace Amine β-Phenylethylamine: Dual Indirect Sympathomimetic and α1-Adrenoceptor Blocking Actions
PEA has dual indirect sympathomimetic and 1-adrenoceptor blocking actions, affecting resistance artery tone through both vasodilation and constriction.
2014·9citations·Deepak Narang et al.·The Journal of Pharmacology and Experimental Therapeutics
The Journal of Pharmacology and Experimental Therapeutics
Rat Brain-Uptake Index for Phenylethylamine and Various Monomethylated Derivatives
Phenylethylamine and its monomethylated derivatives readily cross the blood-brain barrier and distribute evenly in various rat brain areas, aiding in understanding their pharmacological and behavioral effects.
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Characterization of beta-phenylethylamine-induced monoamine release in rat nucleus accumbens: a microdialysis study.
Beta-phenylethylamine increases dopamine levels in the rat nucleus accumbens without affecting monoamine metabolism, making it a potential drug for treating addiction.
1998·43citations·Masato Nakamura et al.·European journal of pharmacology
European journal of pharmacology
Antagonistic effects of β-phenylethylamine on quinpirole- and (−)-sulpiride-induced changes in evoked dopamine release from rat striatal slices
Submicromolar levels of -phenylethylamine can modify dopamine autoreceptor-mediated changes in evoked dopamine release from rat striatal slices.
1998·7citations·S. Yamada et al.·European Journal of Pharmacology
European Journal of Pharmacology
2‐Phenylethylamine: A Modulator of Catecholamine Transmission in the Mammalian Central Nervous System?
2phenylethylamine (phenylethylamine) is a neuromodulator of catecholamine neurotransmission in the central nervous system, despite its low endogenous concentration and low potency in behavioral and pharmacological experiments.
1990·263citations·I. Paterson et al.·Journal of Neurochemistry
Journal of Neurochemistry
Phenylethylamine-induced release of noradrenaline fails to stimulate α1-adrenoceptors modulating [3H]-acetylcholine release in rat atria, but activates α2-adrenoceptors modulating [3H]-serotonin release in the hippocampus
Phenylethylamine-induced release of noradrenaline fails to stimulate 1-adrenoceptors, but activates 2-adrenoceptors, modulating serotonin release in the hippocampus.
1986·5citations·S. Benkirane et al.·Naunyn-Schmiedeberg's Archives of Pharmacology
Naunyn-Schmiedeberg's Archives of Pharmacology