Effect of piroxicam on primary intestinal tumors induced in rats by N-methylnitrosourea.

doi:10.1016/S0304-3835(84)80035-X

Paper

Effect of piroxicam on primary intestinal tumors induced in rats by N-methylnitrosourea.

Published Dec 1, 1984 · Morris Pollard, P. Luckert

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102

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Abstract

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Non-RCT

Animal Study

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Study Snapshot

Piroxicam significantly reduces intestinal tumors in rats infected with N-methylnitrosourea, without causing toxicity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Effect of piroxicam on primary intestinal tumors induced in rats by N-methylnitrosourea.

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References

Are we doing better with large-bowel cancer?

Adjuvant chemotherapy with fluorouracil and semustine, and nonspecific immunotherapy with methanol, showed no benefit for colon cancer patients in a randomized study.

The suppressive effect of piroxicam on autochthonous intestinal tumors in the rat.

Piroxicam significantly reduces intestinal tumor incidence in MAM-treated rats without causing toxicity.

Prolonged antitumor effect of indomethacin on autochthonous intestinal tumors in rats.

Indomethacin effectively prevents or retards intestinal tumor development in rats after exposure to carcinogens, with a relatively constant number of tumors but increased tumor size.

Effect of indomethacin on intestinal tumors induced in rats by the acetate derivative of dimethylnitrosamine.

Indomethacin significantly reduces intestinal tumors induced by the acetate derivative of dimethylnitrosamine in rats, suggesting its potential as a therapeutic agent for intestinal tumors.

Treatment of Chemically-Induced Intestinal Cancers with Indomethacin 1

Indomethacin significantly reduces intestinal tumors in rats exposed to chemical carcinogens, suggesting its potential therapeutic or antipromotional effects.

Inhibition of development of methylnitrosourea-induced rat colon tumors by indomethacin treatment.

Indomethacin treatment effectively inhibits colonic tumor development in rats, potentially preventing colonic cancer in high-risk patients.

Antitumor activity of indomethacin on methylazoxymethanol-induced large bowel tumors in rats.

Indomethacin and hydrocortisone treatment effectively inhibits the development of large bowel tumors in rats, potentially benefiting early stage disease with small tumor cells.

Inhibition by prostaglandin synthesis inhibitors of the induction of epidermal ornithine decarboxylase activity, the accumulation of prostaglandins, and tumor promotion caused by 12-O-tetradecanoylphorbol-13-acetate.

Indomethacin treatment before TPA treatment effectively inhibits epidermal ornithine decarboxylase activity, skin tumor promotion, and skin papilloma formation.

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