The effect of prednisolone on antibody-dependent cell-mediated cytotoxicity and the growth of type I herpes simplex virus in human cells.

Paper

The effect of prednisolone on antibody-dependent cell-mediated cytotoxicity and the growth of type I herpes simplex virus in human cells.

Published Apr 1, 1978 · J. Cooper, C. Daniels, E. F. Trofatter

Investigative ophthalmology & visual science

Q1 SJR score

11

Citations

0

Influential Citations

Semantic Scholar

Abstract

Treatment of human skin and corneal fibroblasts with prednisolone-21-phosphate did not increase the capacity of these cells to replicate type I herpes simplex virus (HSV). The steroid however was found to (1) inhibit human lymphocytes from mediating antibody-dependent cell-mediated cytotoxicity (ADCC) against HSV-infected fibroblasts and (2) suppress the replication of virus in PHA-stimulated human lymphocytes. The data suggest that the exacerbation observed when patients with dendritic keratitis are inadvertently treated with prednisolone may be due to the steroid suppressing ADCC and not by promoting the growth of virus in the corneal cells.

In Vitro Study

Study Snapshot

Prednisolone may exacerbate dendritic keratitis due to suppressing antibody-dependent cell-mediated cytotoxicity, rather than promoting virus growth in corneal cells.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

The effect of prednisolone on antibody-dependent cell-mediated cytotoxicity and the growth of type I herpes simplex virus in human cells.

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References

Citations

The effect of topical ocular corticosteroid administration in dogs with experimentally induced latent canine herpesvirus-1 infection.

Topical ocular corticosteroid administration does not likely result in detectable reactivation of latent canine herpesvirus-1 infection in experimentally infected dogs.

Experimental primary ocular canine herpesvirus-1 infection in adult dogs.

Primary ocular canine herpesvirus-1 infection in adult dogs leads to self-limiting conjunctivitis and ocular viral shedding, with no detectable keratitis or systemic disease.

Characterization of a glucocorticoid receptor and the direct effect of dexamethasone on herpes simplex virus infection of rabbit corneal cells in culture.

Dexamethasone directly increases herpes simplex virus infection in rabbit corneal cells, potentially through the glucocorticoid receptor.

Idoxuridine-liposome therapy for herpes simplex keratitis.

Idoxuridine-liposome therapy is more effective than idoxuridine alone in treating acute and chronic herpetic keratitis.

Scanning and transmission electron microscopic studies of complement-mediated lysis and antibody-dependent cell-mediated cytolysis of herpes simplex virus-infected human fibroblasts.

Antiviral antibody, complement, and leukocytes play distinct roles in lysing herpes simplex virus-infected human fibroblasts, with complement playing a key role in cellular destruction.