E. Sameh, K. Elhady, S. Srour
Mar 26, 2023
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Suez Canal Veterinary Medical Journal. SCVMJ
Abstract
Aspartame is a common artificial sweetener that is thought to be dangerous. On the other hand, stevioside (stevia) a natural sweetener of plant origin was assumed to be a natural alternative to artificial sweeteners. This study aimed to determine whether aspartame or stevioside affected biochemical, sero-biochemical, and immunohistochemical changes in adult rats following six weeks exposure. Forty-eight rats were used and divided into three groups: Group I: the control group, Group II: rats received aspartame (75 mg/kg/day), Group III: rats received stevioside (45 mg/kg/day). All medications were given orally for 6 weeks. Lipid Peroxidation product (MDA); liver glutathione (GSH); nitric oxide (NO); Liver Superoxidase dismutase activity(SOD); catalase (CAT), Low-density lipoprotein (LDL) ; very low lipoprotein (VLDL) ;the cholesterol in the HDL; Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST); Creatinine, Urea, Total proteins were assessed in blood and liver tissue specimens