G. Kennedy
Jan 1, 2001
Citations
0
Influential Citations
32
Citations
Quality indicators
Journal
Critical Reviews in Toxicology
Abstract
In 1986, I published a review of the toxicology of acetamide (CAS #60-35-5), N,N-dimethylacetamide (DMAC CAS # I 27-19-5), N-methylacetamide (MMAC CAS #79-16-3), formamide (CAS #7512-7), N,N-dimethyl-formamide (DMF CAS #6812-2), and N-methylformamide (Mh4F CAS # I 2339-7) in Critical Reviews in Toxicology (Kennedy, 1986). These chemicals continue to have commercial importance, and the information generated in the intervening years has added considerably to our knowledge around the biological consequences of exposure in man. Thus, it is timely to consider updating the information that was reviewed in this journal more than a decade ago. The outline of the presentation is similar in that each chemical is reviewed individually in each of the various sections. It remains true that the biological responses do vary both qualitatively and quantitatively among these six chemicals, and that the type and amount of information available both reflects the biology of the material and its usage or proposed usage. Thus, data for each of the six chemicals is considered separately in each section and similaritieddissimilarities will be handled in the concluding section. Additionally, information on the environmental toxicology of these materials has been greatly expanded during the last 14 years and some of the data that was not in the 1986 review are included.