Effects of agarwood extracts on the central nervous system in mice.

doi:10.1055/S-2006-959599

Paper

Effects of agarwood extracts on the central nervous system in mice.

Published Feb 1, 1993 · H. Okugawa, Reiko Ueda, Katsuhiko Matsumoto

Planta medica

Q2 SJR score

75

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0

Influential Citations

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Abstract

Agarwood (Jinkoh in Japanese) is an Oriental medicine for use as a sedative. Neuropharmacological studies have been conducted with the extracts of petroleum ether, benzene, chloroform, and water from agarwood (Aquilaria sp.; probably Aquilaria malaccensis Benth.) in mice. The benzene extract showed a reducing effect in spontaneous motility, a prolonging effect on hexobarbiturate-induced sleeping time, a hypothermic effect in terms of rectal temperature, and a suppressive effect on acetic acid-writhing by oral administration. Fr. 1 of the three fractions which were obtained from the benzene extract by column chromatography was found to produce more positive effects on these neuropharmacological tests than the original benzene extract. These facts suggest that the benzene extractable compounds of agarwood possess potent central nervous system depressant activities.

Non-RCT

Animal Study

Highly Cited

Study Snapshot

Agarwood extracts, particularly benzene, possess potent central nervous system depressant activities in mice.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Effects of agarwood extracts on the central nervous system in mice.

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References

Citations

In silico molecular docking and molecular dynamic simulation of agarwood compounds with molecular targets of Alzheimer’s disease

Agarwood compounds aquilarisin, aquilarisinin, and aquilarixanthone show potential as potential Alzheimer's disease treatments, but require further experimental validation.

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Agarwood oil, containing biomarkers like aromadendrene II, valencene, phytol, octacosane, caryophyllene oxide, -caryophyllene, hinesol, agarospirol, and agar

Chemical Composition and Potential Properties in Mental Illness (Anxiety, Depression and Insomnia) of Agarwood Essential Oil: A Review

Agarwood essential oil has potential as a sedative and tranquilizing agent for treating mental illnesses like anxiety, depression, and insomnia.

Medicinal uses of agarwood

Different parts of Aquilaria plants, not just agarwood, show potential for treating abdominal pain and sedation, with potential for sustainable use in traditional medicine.

An integrated chemical characterization based on FT-NIR, GC-MS and LC-MS for the comparative metabolite profiling of wild and cultivated agarwood.

This study developed a multi-technology platform to identify key chemical markers to distinguish wild and cultivated agarwood, aiding in quality control of this valuable resource.

Fingerprint combining with quantitative analysis of multi-components by single marker for quality control of Chenxiang Huaqi tablets.

HPLC fingerprinting combined with the QAMS method effectively identifies and evaluates the quality of Chenxiang Huaqi tablets, a traditional Chinese medicine.

Agarwood Alcohol Extract Protects against Gastric Ulcer by Inhibiting Oxidation and Inflammation

Agarwood alcohol extracts can reduce the occurrence and development of gastric ulcers by inhibiting oxidation and inflammation.

Economic Value of Agarwood and Its Prospects of Cultivation

Agarwood has high economic value and potential for sustainable production in Nepal's hill agroecosystems using new technology, potentially providing a new economy for the region.

Novel serotonin-boosting effect of incense smoke from Kynam agarwood in mice: the involvement of multiple neuroactive pathways.

Agarwood incense smoke's anti-anxious and anti-depressant effects are likely linked to increased serotonin levels and multiple neuroactive pathways in mice.