Effects of the 5 alpha‐reductase inhibitor dutasteride on gene expression in prostate cancer xenografts

doi:10.1002/pros.21022

Paper

Effects of the 5 alpha‐reductase inhibitor dutasteride on gene expression in prostate cancer xenografts

Published Dec 1, 2009 · L. Schmidt, Kevin M. Regan, S. K. Anderson

The Prostate

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Abstract

In the prostate, androgens play a crucial role in normal and cancerous growth; hence the androgenic pathway has become a target of therapeutic intervention. Dutasteride is a 5 alpha‐reductase (5AR) inhibitor currently being evaluated both for chemoprevention and treatment of prostate cancer. Dutasteride inhibits both 5AR I and II enzymes, effectively blocking conversion of testosterone to dihydrotestosterone (DHT) in the prostate. This greatly reduces the amount of the active ligand DHT available for binding to the androgen receptor (AR) and stimulating proliferation, making this a good candidate for chemoprevention of prostate cancer. In this study, we sought to determine how dutasteride is functioning at the molecular level, using a prostate cancer xenograft model.

In Vitro Study

Study Snapshot

Dutasteride effectively reduces testosterone to dihydrotestosterone in prostate cancer xenografts, potentially preventing prostate cancer by inhibiting androgen-dependent growth.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Effects of the 5 alpha‐reductase inhibitor dutasteride on gene expression in prostate cancer xenografts

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Citations

The inhibition of steroid hormones determines the fate of IPC-366 tumor cells, highlighting the crucial role of androgen production in tumor processes.

Inhibiting steroid hormone production can reduce cell viability and tumor growth in inflammatory mammary cancer, potentially improving prognosis.

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