Paper
Effects of cannabidiol in males and females in two different rat models of depression
Published Mar 15, 2019 · L. Shbiro, D. Hen-Shoval, N. Hazut
Physiology & Behavior
Q2 SJR score
58
Citations
3
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Non-RCT
Animal StudyStudy Snapshot
CBD shows potential in treating mental disorders with symptoms of helplessness and anhedonia, showing similar effects in both male and female rat models of depression.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
Sign up to use Study Snapshot
Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.
Full text analysis coming soon...
References
Major depressive disorder
Major depressive disorder (MDD) may be associated with extensive dental disease, and dentists can help identify patients with occult MDD and provide supportive dental care.
2020·2150citations·Navneet Bains et al.·Functional Analysis in Clinical Treatment
Functional Analysis in Clinical Treatment
Acute oral cannabidiolic acid methyl ester reduces depression-like behavior in two genetic animal models of depression
HU-580 shows potential as an antidepressant medication by reducing depression-like behavior in two genetic animal models of depression.
2018·29citations·D. Hen-Shoval et al.·Behavioural Brain Research
Behavioural Brain Research
Antidepressant-like effect induced by Cannabidiol is dependent on brain serotonin levels
Cannabidiol's antidepressant-like effects in mice are dependent on brain serotonin levels, suggesting a potential mechanism for its potential therapeutic use in depression.
2018·88citations·A. Sales et al.·Progress in Neuro-Psychopharmacology and Biological Psychiatry
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Cannabis use, attitudes, and legal status in the U.S.: A review.
Cannabis use and disorders in adults have increased in the U.S., with medical marijuana laws having little effect on adolescents and recreational marijuana laws likely to lower price and availability, potentially increasing use.
2017·422citations·Hannah Carliner et al.·Preventive medicine
Preventive medicine
Chronic Adolescent Δ9-Tetrahydrocannabinol Treatment of Male Mice Leads to Long-Term Cognitive and Behavioral Dysfunction, Which Are Prevented by Concurrent Cannabidiol Treatment
Chronic adolescent THC use can lead to long-term cognitive and behavioral deficits, but cotreatment with CBD can prevent these deficits.
2017·93citations·Michelle N. Murphy et al.·Cannabis and Cannabinoid Research
Cannabis and Cannabinoid Research
Citations
Cannabidiol Modulates Neuroinflammatory and Estrogen-Related Pathways in a Sex-Specific Manner in a Chronic Stress Model of Depression
CBD's antidepressant effect is sex-specific, with hippocampal neuroinflammatory and estrogenic pathways playing a key role in males.
2025·0citations·Uri Bright et al.·Cells
Cells
Chronic cannabidiol administration modulates depressive and cognitive alterations induced by social isolation in male mice
Chronic CBD administration has potential antidepressant and neuroprotective effects in social isolation-induced depressive models, but its anxiogenic effects in non-stressed mice require further investigation.
2024·0citations·Marcel S.S. Lucindo et al.·Behavioural Brain Research
Behavioural Brain Research
Cannabidiol Modulates Neuroinflammatory Markers in a PTSD Model Conducted on Female Rats
CBD effectively inhibits PTSD-like behaviors and suppresses neuroinflammation in a PTSD model in female rats.
2024·0citations·A. Portugalov et al.·Biomolecules
Biomolecules
An overview of major depression disorder: The endocannabinoid system as a potential target for therapy.
The endocannabinoid system shows potential as a target for treating major depressive disorder, with CBD showing potential as a treatment for various neurodegenerative diseases.
2024·0citations·Sergio Zarazúa-Guzmán et al.·Basic & clinical pharmacology & toxicology
Basic & clinical pharmacology & toxicology
Cannabis and anhedonia: A systematic review
Initial anhedonia predisposes individuals to cannabis use, and subsequent consumption significantly intensifies the anhedonia experienced, particularly in adolescents and individuals with mental disorders.
2024·0citations·C. Poyatos-Pedrosa et al.·Psychiatry Research
Psychiatry Research