Effects of triethyllead chloride on hepatic microsomal N- and C-oxygenation of N,N-dimethylaniline in rats.

doi:10.1016/0041-008X(84)90289-8

Paper

DOI: 10.1016/0041-008X(84)90289-8

Effects of triethyllead chloride on hepatic microsomal N- and C-oxygenation of N,N-dimethylaniline in rats.

Published Jul 1, 1984 · A. Odenbro, E. Arrhenius

Toxicology and applied pharmacology

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Study Snapshot

Triethyllead chloride increases microsomal N-oxygenation in rats, potentially potentiating the tumor-inducing characteristics of carcinogenic aromatic amines.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

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Effects of various in vitro conditions on hepatic microsomal N- and C-oxygenation of aromatic amines.

Microsomal N-oxygenation of aromatic amines in rat liver leads to reactive metabolites, while C-oxygenation yields harmless metabolites, and detergent treatment affects both processes.

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Effects in vitro of 2-aminofluorene or electrophilic agents on hepatic microsomal N- and C-oxygenation of aromatic amines.

2-aminofluorene is 100 times more effective in inhibiting microsomal C-oxygenation of aromatic amines than dimethylaniline, and adrenal-dependent stress amplifies this shift towards the deleterious N-oxygenation pathway.

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Citations

DOI:

Lead hepatotoxicity & potential health effects.

Lead exposure can cause hepatotoxicity and potentially damage extrahepatic systems, including the cardiovascular system.

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Effects of triethyl lead chloride on oestradiol metabolism in the female rat liver microsomal fraction.

Triethyl lead chloride decreases enzyme activities that metabolize oestradiol-17 beta in female rat liver microsomal fractions, potentially impacting oestradiol metabolism in vivo.

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MOLECULAR INTERACTION BEHIND THE TOXICITY OF LEAD CONTAMINATION

This review article explains the molecular events behind lead contamination, highlighting the need for policy makers to implement effective policies to reduce lead contamination in developing countries.

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