A. Freeman, M. Spirtes
1963
Citations
0
Influential Citations
65
Citations
Quality indicators
Journal
Biochemical pharmacology
Abstract
Abstract Different techniques were employed to study the effects of chlorpromazine on the permeability of human erythrocytes to various compounds. Preliminary experiments indicated that the drug reduced the rate of hemolysis in the presence of isotonic urea or glycerol. In protecting human red blood cells against hypotonic hemolysis, chlorpromazine and trifluoperazine were found to be active at concentrations as low as 7.5 × 10 −6 M and 10 −6 M, respectively. Chlorpromazine sulfoxide, a weak tranquilizer, gave no protection even at concentrations as high as 10 −3 M. These effects correlated well with the clinical potency of the compounds tested and also varied directly with the amounts of each drug adsorbed by the erythrocytes.