Synergistic Effects between Conventional Antibiotics and 2-Aminoimidazole-Derived Antibiofilm Agents

doi:10.1128/AAC.01418-09

Paper

Synergistic Effects between Conventional Antibiotics and 2-Aminoimidazole-Derived Antibiofilm Agents

Published May 1, 2010 · S. Rogers, R. W. Huigens, J. Cavanagh

Antimicrobial Agents and Chemotherapy

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179

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Abstract

ABSTRACT 2-Aminoimidazoles are an emerging class of small molecules that possess the ability to inhibit and disperse biofilms across bacterial order, class, and phylum. Herein, we report the synergistic effect between a 2-aminoimidazole/triazole conjugate and antibiotics toward dispersing preestablished biofilms, culminating with a 3-orders-of-magnitude increase of biofilm dispersion toward Staphylococcus aureus biofilms. Furthermore, we document that the 2-aminoimidazole/triazole conjugate will also resensitize multidrug-resistant strains of bacteria to the effects of conventional antibiotics, including methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Acinetobacter baumannii.

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Study Snapshot

A 2-aminoimidazole/triazole conjugate and antibiotics effectively disperse and resensitize multidrug-resistant bacteria, improving treatment outcomes.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Synergistic Effects between Conventional Antibiotics and 2-Aminoimidazole-Derived Antibiofilm Agents

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References

Controlling Bacterial Biofilms

Biofilms are resistant to common therapeutic approaches, making them a major factor in the morbidity and mortality of infectious diseases.

Amide isosteres of oroidin: assessment of antibiofilm activity and C. elegans toxicity.

Oroidin analogues effectively inhibit P. aeruginosa biofilm development and are nontoxic to C. elegans development, making them potential antimicrobial agents.

A 2-aminobenzimidazole that inhibits and disperses gram-positive biofilms through a zinc-dependent mechanism.

The 2-aminobenzimidazole effectively inhibits and disperses gram-positive biofilms, potentially through a zinc-chelating mechanism, making it a potential antimicrobial agent.

Evaluation of dihydrooroidin as an antifouling additive in marine paint.

Dihydrooroidin (DHO) is an effective, non-cytotoxic, paint-based antifouling agent for marine structures and vessels, effectively inhibiting Halomonas pacifica biofilms at 100 M.

Inhibition of Acinetobacter baumannii, Staphylococcus aureus and Pseudomonas aeruginosa biofilm formation with a class of TAGE-triazole conjugates.

TAGE-triazole conjugates effectively inhibit biofilm formation against Acinetobacter baumannii, Staphylococcus aureus, and Pseudomonas aeruginosa, with one compound showing the most potent inhibitory effect against Staphylococcus aureus

Citations

Inhibitory effect of Bacillus velezensis 1273 strain cell-free supernatant against developing and preformed biofilms of Staphylococcus aureus and MRSA.

Bacillus velezensis 1273 strain cell-free supernatant effectively inhibits the growth of Staphylococcus aureus and MRSA, reducing biofilm formation and promoting antimicrobial resistance.

Recent advances in the development of bacterial response regulators inhibitors as antibacterial and/or antibiotic adjuvant agent: A new approach to combat bacterial resistance.

Targeting bacterial response regulators with inhibitors shows potential as a new approach to combat bacterial resistance and prevent resistance development.

Fosfomycin Enhances the Inhibition Ability of Linezolid Against Biofilms of Vancomycin-Resistant Enterococcus faecium in vitro

Linezolid combined with fosfomycin has a stronger inhibitory effect on vancomycin-resistant Enterococcus faecium biofilm formation than linezolid alone.

Glycosyl hydrolase from Pseudomonas fluorescens inhibits the biofilm formation of Pseudomonads

PslG PF, a glycosyl hydrolase from Pseudomonas fluorescens, effectively inhibits biofilm formation and disassembles preformed biofilms in various Pseudomonas species, offering potential as a broad-spectrum inhibitor of biofilm

Antimicrobial effects of XF drugs against Candida albicans and its biofilms

XF-73 and XF-70 show potential as new antifungal drugs for treating topical infections caused by Candida albicans, with potential for further development as photodynamic therapy agents.

Biofilm modifiers: The disparity in paradigm of oral biofilm ecosystem.

Modifying oral biofilm ecology may help prevent infections and reduce periodontal diseases, with nanotechnology advances potentially leading to novel strategies for infection control.

Down-regulation of β-lactam antibiotics resistance and biofilm formation by Staphylococcus epidermidis is associated with isookanin

Isookanin effectively inhibits biofilm formation in Staphylococcus epidermidis, improving antibiotic susceptibility and providing guidance for treating antibiotic resistance caused by biofilm.

Bacterial envelope stress responses: Essential adaptors and attractive targets.

Bacterial envelope stress responses are attractive targets for developing new treatments and repurposing existing antibiotics to combat antimicrobial resistance.