The Effects of a Hyaluronan Lotion with a Molecular Weight of around 50 - 110 kDa on the Aged Atrophic Skin

doi:10.4236/JCDSA.2014.43021

Paper

The Effects of a Hyaluronan Lotion with a Molecular Weight of around 50 - 110 kDa on the Aged Atrophic Skin

Published Apr 29, 2014 · Asako Ito

Journal of Cosmetics, Dermatological Sciences and Applications

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Abstract

Background: Hyaluronic acids act upon keratinocytes via CD44 receptors and regulate proliferation and differentiation. Some cosmetic hyaluronan lotions manufactured based upon the fact are nowadays available. Aims: To evaluate a cosmetic hyaluronan lotion (Dr. Fukaya’s skin repair lotion or Hyaluprotect) from the viewpoint of anti-aging effects and to consider its mechanism. Patients/Methods: In ten healthy volunteers at the age over 60, immunohistochemical research of the biopsied skin was performed before and after the application of the hyaluronan lotion for two weeks. Results: Expression of PCNA in the lower epidermis increased in 8 of 10 subjects. Filaggrin expression of the upper epidermis increased in 6 subjects. 11βHSD1 decreased in 5 subjects and 11βHSD2 increased in 5 subjects. Conclusions: The proliferative and differentiative effects of the hyaluronan lotion upon keratinocytes were confirmed immunohistologically. There is a possibility that hyaluronic acids work through the regulation of corticosteroids by 11βHSD1 and 11βHSD2.

Non-RCT

Study Snapshot

Hyaluronan lotions may have anti-aging effects by regulating keratinocyte proliferation and differentiation, potentially through the regulation of corticosteroids by 11HSD1 and 11HSD2.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

The Effects of a Hyaluronan Lotion with a Molecular Weight of around 50 - 110 kDa on the Aged Atrophic Skin

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References

Selective matrix (hyaluronan) interaction with CD44 and RhoGTPase signaling promotes keratinocyte functions and overcomes age-related epidermal dysfunction.

Topical applications of different sizes of hyaluronan can regulate epidermal proliferation, differentiation, and barrier function in aged mouse skin, potentially offering novel therapeutic approaches for aging-related skin disorders.

Inhibition of putative hyalurosome platform in keratinocytes as a mechanism for corticosteroid-induced epidermal atrophy.

Corticosteroids cause skin atrophy by targeting the CD44/EGFR/HAS platform, which may lead to new treatment and prevention strategies for corticosteroid-induced skin atrophy.

The Hyaluronan Receptor for Endocytosis (HARE) Activates NF-κB-mediated Gene Expression in Response to 40–400-kDa, but Not Smaller or Larger, Hyaluronans*

The HARE receptor for endocytosis activates NF-B-mediated gene expression only with optimally sized hyaluronan, suggesting it may serve as a sensing system for tissue ECM stress.

Hyaluronic acid, an important factor in the wound healing properties of amniotic fluid: In vitro studies of re-epithelialisation in human skin wounds

Amniotic fluid promotes accelerated re-epithelialisation in human skin wounds, with hyaluronic acid being an important ingredient in this process.

Hyaluronan Fragments Improve Wound Healing on In Vitro Cutaneous Model through P2X7 Purinoreceptor Basal Activation: Role of Molecular Weight

Medium-sized hyaluronan fragments (MMW-HA) between 100 and 300 kDa effectively promote wound healing by activating the P2X7 receptor, offering a potential new therapeutic strategy for skin wound healing.

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