Metabolic Effects of Intermittent Fasting.

doi:10.1146/annurev-nutr-071816-064634

Paper

Metabolic Effects of Intermittent Fasting.

Published Aug 21, 2017 · R. Patterson, Dorothy D. Sears

Annual review of nutrition

Q1 SJR score

525

Citations

20

Influential Citations

Full textSemantic Scholar

Abstract

The objective of this review is to provide an overview of intermittent fasting regimens, summarize the evidence on the health benefits of intermittent fasting, and discuss physiological mechanisms by which intermittent fasting might lead to improved health outcomes. A MEDLINE search was performed using PubMed and the terms "intermittent fasting," "fasting," "time-restricted feeding," and "food timing." Modified fasting regimens appear to promote weight loss and may improve metabolic health. Several lines of evidence also support the hypothesis that eating patterns that reduce or eliminate nighttime eating and prolong nightly fasting intervals may result in sustained improvements in human health. Intermittent fasting regimens are hypothesized to influence metabolic regulation via effects on (a) circadian biology, (b) the gut microbiome, and (c) modifiable lifestyle behaviors, such as sleep. If proven to be efficacious, these eating regimens offer promising nonpharmacological approaches to improving health at the population level, with multiple public health benefits.

Systematic Review

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Study Snapshot

Intermittent fasting regimens may promote weight loss and improve metabolic health, potentially through effects on circadian biology, gut microbiome, and modifiable lifestyle behaviors like sleep.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Metabolic Effects of Intermittent Fasting.

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References

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Prolonged nightly fasting may reduce the risk of breast cancer recurrence by improving glucoregulation and sleep duration in women with early-stage breast cancer.

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Intermittent energy restriction (IER) may reduce tumor rates in mice, but long-term human studies are needed to confirm its efficacy and safety in obese, overweight, and normal-weight individuals.

Citations

Changes in haptoglobin genotype-based gene expressions upon the observance of dawn-to-dusk intermittent fasting: a prospective cohort study on overweight and obese individuals

Intermittent fasting can enhance antioxidative stress response and reduce systemic inflammation, with haptoglobin genotype playing a key role in shaping the body's response to dietary modifications like fasting.

EFEK PUASA TERHADAP BIOMARKER HEPAR: SEBUAH TINJAUAN PUSTAKA SISTEMATIS

Fasting can reduce inflammation, making it a beneficial dietary intervention for long-term health if done consistently and long term.

Religious and Traditional Fasting May Be an Alternative Method to Tackle Global Health Threats and the Epidemic of Obesity

Religious and traditional fasting practices may be a promising strategy for weight loss, improving metabolic health, and combating the obesity pandemic.

Yogic Concept of Diet, Mindful Eating and Fasting

Yogaic diet, mindful eating, and fasting are crucial for maintaining good health and spiritual upliftment.

Every-other-day fasting inhibits pyroptosis while regulating bile acid metabolism and activating TGR5 signaling in spinal cord injury

Every-other-day fasting (EODF) can improve motor function and reduce secondary injury in spinal cord injury by regulating bile acid metabolism, activating TGR5 signaling, and inhibiting the NLRP3 pyroptosis pathway.

Health Impact Due to Prolonged Water Only Fast by Jain Monk: A Case Report

Prolonged water only fasting can cause fluctuating blood levels, potentially impacting bodily organs' functioning.