Paper
The anti-inflammatory effects of sanguinarine and its modulation of inflammatory mediators from peritoneal macrophages.
Published Aug 15, 2012 · X. Niu, Ting Fan, Weifeng Li
European journal of pharmacology
Q1 SJR score
101
Citations
1
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Non-RCT
Animal Study
Highly CitedStudy Snapshot
Sanguinarine effectively inhibits inflammation and its molecular mechanisms support its naturopathic use for treating various human inflammatory diseases.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Antiplatelet effect of sanguinarine is correlated to calcium mobilization, thromboxane and cAMP production.
Sanguinarine is a potent antiplatelet agent that activates adenylate cyclase, inhibits platelet calcium mobilization, TXB(2) production, and suppresses COX-1 enzyme activity, potentially having therapeutic potential for cardiovascular diseases related to platelet aggregation.
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Resolution of inflammation: the beginning programs the end
Acute inflammation resolves itself in the first few hours, with granulocytes, resolvins, and protectins playing key roles in promoting apoptosis and cytokine release.
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Nature Immunology
The Benzo[c]phenanthridine Alkaloid, Sanguinarine, Is a Selective, Cell-active Inhibitor of Mitogen-activated Protein Kinase Phosphatase-1*
Sanguinarine, a plant alkaloid, is a potent and selective inhibitor of MKP-1, which is overexpressed in human tumors and can protect cells from apoptosis.
2005·178citations·A. Vogt et al.·Journal of Biological Chemistry
Journal of Biological Chemistry
Antiinflammatory and chronic toxicity study of the leaves of Ageratum conyzoides L. in rats.
The hydroalcoholic extract of Ageratum conyzoides leaves effectively reduces inflammation in rats without causing hepatotoxicity.
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2025·0citations·Wenyuan Xu et al.·Aquaculture Reports
Aquaculture Reports
Redesigning Berberines and Sanguinarines to Target Soluble Epoxide Hydrolase for Enhanced Anti-Inflammatory Efficacy.
Redesigning natural compounds like berberine and sanguinarine with strategic urea modifications and hydrogenated frameworks, creates novel soluble Epoxide Hydrolase inhibitors with enhanced anti-inflammatory efficacy.
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Industrial Crops and Products
Identification of sanguinarine as c-MYC transcription inhibitor through enhancing the G-quadruplex-NM23-H2 interactions.
Sanguinarine is a potent c-MYC transcription inhibitor that inhibits cancer cell growth by enhancing G4-protein interactions.
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Frontiers in Pharmacology
Effects of a dietary isoquinoline alkaloids blend on gut antioxidant capacity and gut barrier of young broilers
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Bioactive Compounds from Plant Origin as Natural Antimicrobial Agents for the Treatment of Wound Infections
Plant-derived bioactive compounds show potential as natural antimicrobial agents for treating wound infections, potentially combating drug-resistant bacteria.
2024·11citations·Katarzyna Pacyga et al.·International Journal of Molecular Sciences
International Journal of Molecular Sciences