Elisa Placidi, L. Marciani, C. Hoad
Jul 1, 2012
Citations
0
Influential Citations
28
Citations
Journal
Alimentary Pharmacology & Therapeutics
Abstract
Loperamide (LOP) is an anti‐diarrhoeal agent which is thought to act largely by slowing transit with an uncertain effect on the fluid content of the small and large bowel in humans. Adding simethicone (SIM) to LOP improves its efficacy, but the mechanism of interaction is unclear. Novel MRI techniques to assess small bowel water content (SBWC) have shown that mannitol solutions markedly increase SBWC and can be used as a model of diarrhoea.