H. Tomosaka, S. Omata, E. Hasegawa
Jul 23, 1997
Citations
0
Influential Citations
12
Citations
Quality indicators
Journal
Bioscience, biotechnology, and biochemistry
Abstract
Some derivatives of 9-aminoacridine (1) were synthesized, and their frameshift mutagenicity and DNA binding affinity were studied. The introduction of a methyl group into the acridine ring of 1 reduced the mutagenic activity and the intercalative DNA binding affinity, while the introduction of chlorine increased them. Halogenated derivatives of 1 showed higher toxicity against Salmonella typhimurium TA1537.