F. Vanmolkot, J. Hoon
Jul 1, 2006
Citations
0
Influential Citations
23
Citations
Journal
Clinical Pharmacology & Therapeutics
Abstract
Sumatriptan, a 5‐hydroxytryptamine (HT)1B/1D receptor agonist, is an effective acute antimigraine drug. Because of its vasoconstrictor activity, it is contraindicated in patients at high risk for adverse cardiovascular events. Acute antimigraine drugs without vasoconstrictor effects are currently being developed, and sensitive, noninvasive techniques by which to detect drug‐induced vascular effects would facilitate their clinical development. The effects of sumatriptan on aortic blood pressure, stiffness, and pressure waveform have not been assessed previously in detail.